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    Autoantibodies against tumor-associated antigens in sputum as biomarkers for lung cancer.

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    Author
    Li, Ning
    Holden, Van K
    Deepak, Janaki
    Todd, Nevins W
    Jiang, Feng
    Date
    2021-01
    Journal
    Translational Oncology
    Publisher
    Neoplasia Press, Inc.
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.tranon.2020.100991
    Abstract
    Tumor antigens (TAs) can initiate host immune responses and produce TA-associated autoantibody (TAAbs), potential cancer biomarkers. Sputum is directly generated from the upper and lower airways, and thus can be used as a surrogate sample for the diagnosis of lung cancer based on molecular analysis. To develop sputum TAAb biomarkers for the early detection of lung cancer, the leading cause of cancer death, we probed a protein microarray containing more than 9,000 antigens with sputum supernatants of a discovery set of 30 lung cancer patients and 30 cancer-free smokers. Twenty-eight TAs with higher reactivity in sputum of lung cancer cases vs. controls were identified. The diagnostic significance of TAAbs against the TAs was determined by enzyme-linked immunosorbent assays (ELISAs) in sputum of the discovery set and additional 166 lung cancer patients and 213 cancer-free smokers (validation set). Three sputum TAAbs against DDX6, ENO1, and 14–3-3ζ were developed as a biomarker panel with 81% sensitivity and 83% specificity for diagnosis of lung cancer, regardless of stages, locations, and histological types of lung tumors. This study provides the first evidence that sputum TAAbs could be used as biomarkers for the early detection of lung cancer.
    Rights/Terms
    Copyright © 2020. Published by Elsevier Inc.
    Keyword
    Autoantibodies
    Biomarkers
    Diagnosis
    Lung cancer
    Sputum
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14310
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.tranon.2020.100991
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    UMB Open Access Articles 2021

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