Incidence of symptomatic venous thromboembolism following hospitalization for coronavirus disease 2019: Prospective results from a multi-center study.
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Author
Rashidi, FaridBarco, Stefano
Kamangar, Farin
Heresi, Gustavo A
Emadi, Ashkan
Kaymaz, Cihangir
Jansa, Pavel
Reis, Abilio
Rashidi, Arash
Taghizadieh, Ali
Rezaeifar, Parisa
Moghimi, Minoosh
Ghodrati, Samad
Mozafari, Abolfazl
Foumani, Ali Alavi
Tahamtan, Ouria
Rafiee, Effat
Abbaspour, Zahra
Khodadadi, Kasra
Alamdari, Golsa
Boodaghi, Yasman
Rezaei, Maryam
Muhammadi, Muhammad Javad
Abbasi, Meysam
Movaseghi, Fatemeh
Koohi, Ata
Shakourzad, Leila
Ebrahimi, Fatemeh
Radvar, Sarvin
Amoozadeh, Maryam
Fereidooni, Fatemeh
Naseari, Hanieh
Movalled, Kobra
Ghorbani, Ozra
Ansarin, Khalil
Date
2021-01Journal
Thrombosis ResearchPublisher
Elsevier Ltd.Type
Article
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Background: Thrombosis and pulmonary embolism appear to be major causes of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients. However, few studies have focused on the incidence of venous thromboembolism (VTE) after hospitalization for COVID-19. Methods: In this multi-center study, we followed 1529 COVID-19 patients for at least 45 days after hospital discharge, who underwent routine telephone follow-up. In case of signs or symptoms of pulmonary embolism (PE) or deep vein thrombosis (DVT), they were invited for an in-hospital visit with a pulmonologist. The primary outcome was symptomatic VTE within 45 days of hospital discharge. Results: Of 1529 COVID-19 patients discharged from hospital, a total of 228 (14.9%) reported potential signs or symptoms of PE or DVT and were seen for an in-hospital visit. Of these, 13 and 12 received Doppler ultrasounds or pulmonary CT angiography, respectively, of whom only one patient was diagnosed with symptomatic PE. Of 51 (3.3%) patients who died after discharge, two deaths were attributed to VTE corresponding to a 45-day cumulative rate of symptomatic VTE of 0.2% (95%CI 0.1%–0.6%; n = 3). There was no evidence of acute respiratory distress syndrome (ARDS) in these patients. Other deaths after hospital discharge included myocardial infarction (n = 13), heart failure (n = 9), and stroke (n = 9). Conclusions: We did not observe a high rate of symptomatic VTE in COVID-19 patients after hospital discharge. Routine extended thromboprophylaxis after hospitalization for COVID-19 may not have a net clinical benefit. Randomized trials may be warranted.Rights/Terms
Copyright © 2020 Elsevier Ltd. All rights reserved.Identifier to cite or link to this item
http://hdl.handle.net/10713/14308ae974a485f413a2113503eed53cd6c53
10.1016/j.thromres.2020.12.001
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