• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2021
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2021
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Commentary: Does an expeditious evaluation for high-acuity lung transplant recipients make a difference?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Shah, Aakash
    Pasrija, Chetan
    Madathil, Ronson J
    Lau, Christine L
    Date
    2020-03-19
    Journal
    Journal of Thoracic and Cardiovascular Surgery
    Publisher
    Mosby Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.jtcvs.2020.03.016
    Abstract
    A growing body of research has suggested that people with schizophrenia (SZ) exhibit altered patterns of functional and anatomical brain connectivity. For example, many previous resting state functional connectivity (rsFC) studies have shown that, compared to healthy controls (HC), people with SZ demonstrate hyperconnectivity between subregions of the thalamus and sensory cortices, as well as hypoconnectivity between subregions of the thalamus and prefrontal cortex. In addition to thalamic findings, hypoconnectivity between cingulo-opercular brain regions thought to be involved in salience detection has also been commonly reported in people with SZ. However, previous studies have largely relied on seed-based analyses. Seed-based approaches require researchers to define a single a priori brain region, which is then used to create a rsFC map across the entire brain. While useful for testing specific hypotheses, these analyses are limited in that only a subset of connections across the brain are explored. In the current manuscript, we leverage novel network statistical techniques in order to detect latent functional connectivity networks with organized topology that successfully differentiate people with SZ from HCs. Importantly, these techniques do not require a priori seed selection and allow for whole brain investigation, representing a comprehensive, data-driven approach to determining differential connectivity between diagnostic groups. Across two samples, (Sample 1: 35 SZ, 44 HC; Sample 2: 65 SZ, 79 HC), we found evidence for differential rsFC within a network including temporal and thalamic regions. Connectivity in this network was greater for people with SZ compared to HCs. In the second sample, we also found evidence for hypoconnectivity within a cingulo-opercular network of brain regions in people with SZ compared to HCs. In summary, our results replicate and extend previous studies suggesting hyperconnectivity between the thalamus and sensory cortices and hypoconnectivity between cingulo-opercular regions in people with SZ using data-driven statistical and graph theoretical techniques.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14296
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jtcvs.2020.03.016
    Scopus Count
    Collections
    UMB Open Access Articles 2021

    entitlement

    Related articles

    • Antibody induction therapy for lung transplant recipients.
    • Authors: Penninga L, Møller CH, Penninga EI, Iversen M, Gluud C, Steinbrüchel DA
    • Issue date: 2013 Nov 27
    • Native lung complications in single-lung transplant recipients and the role of pneumonectomy.
    • Authors: King CS, Khandhar S, Burton N, Shlobin OA, Ahmad S, Lefrak E, Barnett SD, Nathan SD
    • Issue date: 2009 Aug
    • Editorial Commentary: Chronic Lung Allograft Dysfunction in Lung Transplant Recipients: Another Piece of the Puzzle.
    • Authors: Gardiner BJ, Snydman DR
    • Issue date: 2016 Feb 1
    • Lung Cancer Prognosis in Elderly Solid Organ Transplant Recipients.
    • Authors: Sigel K, Veluswamy R, Krauskopf K, Mehrotra A, Mhango G, Sigel C, Wisnivesky J
    • Issue date: 2015 Oct
    • Survival in Adult Lung Transplant Recipients Receiving Pediatric Versus Adult Donor Allografts.
    • Authors: Hayes D Jr, Whitson BA, Ghadiali SN, Lloyd EA, Tobias JD, Mansour HM, Black SM
    • Issue date: 2015 Oct
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.