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    Safety and immunogenicity of co-administration of meningococcal type A and measles-rubella vaccines with typhoid conjugate vaccine in children aged 15-23 months in Burkina Faso.

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    Author
    Sirima, Sodiomon B
    Ouedraogo, Alphonse
    Barry, Nouhoun
    Siribie, Mohamadou
    Tiono, Alfred B
    Nébié, Issa
    Konaté, Amadou T
    Berges, Gloria Damoaliga
    Diarra, Amidou
    Ouedraogo, Moussa
    Soulama, Issiaka
    Hema, Alimatou
    Datta, Shrimati
    Liang, Yuanyuan
    Rotrosen, Elizabeth T
    Tracy, J Kathleen
    Jamka, Leslie P
    Neuzil, Kathleen M
    Laurens, Matthew B
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    Date
    2021-01-08
    Journal
    International journal of infectious diseases
    Type
    Article
    
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    https://doi.org/10.1016/j.ijid.2020.10.103
    Abstract
    Objectives: The World Health Organization pre-qualified single-dose typhoid conjugate vaccine (TCV) and requested data on co-administration with routine vaccines. The co-administration of Typbar TCV (Bharat Biotech International) with routine group A meningococcal conjugate vaccine (MCV-A) and measles–rubella (MR) vaccine was tested. Methods: This was a double-blind, randomized controlled trial performed in Ouagadougou, Burkina Faso. Children were recruited at the 15-month vaccination visit and were assigned randomly (1:1:1) to three groups. Group 1 children received TCV plus control vaccine (inactivated polio vaccine) and MCV-A 28 days later; group 2 children received TCV and MCV-A; group 3 children received MCV-A and control vaccine. Routine MR vaccine was administered to all participants. Safety was assessed at 0, 3, and 7 days after immunization, and unsolicited adverse events and serious adverse events were assessed for 28 days and 6 months after immunization, respectively. Results: A total of 150 children were recruited and vaccinated. Solicited symptoms were infrequent and similar for TCV and control recipients, as were adverse events (group 1, 61.2%; group 2, 64.0%; group 3, 68.6%) and serious adverse events (group 1, 2.0%; group 2, 8.0%; group 3, 5.9%). TCV generated robust immunity without interference with MCV-A vaccine. Conclusions: TCV can be safely co-administered at 15 months with MCV-A without interference. This novel study on the co-administration of TCV with MCV-A provides data to support large-scale uptake in sub-Saharan Africa.
    Keyword
    Burkina Faso
    Co-administration
    Measles–rubella vaccine
    Meningococcal vaccines
    Sub-Saharan Africa
    Typhoid conjugate vaccine
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14289
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijid.2020.10.103
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