• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Wang, Xin
    Li, You
    Deloria-Knoll, Maria
    Madhi, Shabir A.
    Cohen, Cheryl
    Ali, Asad
    Basnet, Sudha
    Bassat, Quique
    Brooks, W. Abdullah
    Chittaganpitch, Malinee
    Echavarria, Marcela
    Fasce, Rodrigo A.
    Goswami, Doli
    Hirve, Siddhivinayak
    Homaira, Nusrat
    Howie, Stephen R.C.
    Kotloff, Karen L.
    Khuri-Bulos, Najwa
    Krishnan, Anand
    Lucero, Marilla G.
    Lupisan, Socorro
    Mira-Iglesias, Ainara
    Moore, David P.
    Moraleda, Cinta
    Nunes, Marta
    Oshitani, Histoshi
    Owor, Betty E.
    Polack, Fernando P.
    O'Brien, Katherine L.
    Rasmussen, Zeba A.
    Rath, Barbara A.
    Salimi, Vahid
    Scott, J. Anthony G.
    Simões, Eric A.F.
    Strand, Tor A.
    Thea, Donald M.
    Treurnicht, Florette K.
    Vaccari, Linda C.
    Yoshida, Lay Myint
    Zar, Heather J.
    Campbell, Harry
    Nair, Harish
    Libster, Romina
    Otieno, Grieven
    Joundi, Imane
    Broor, Shobha
    Nicol, Mark
    Amarchand, Ritvik
    Shi, Ting
    López-Labrador, F. Xavier
    Baker, Julia M.
    Jamison, Alexandra
    Choudekar, Avinash
    Juvekar, Sanjay
    Obermeier, Patrick
    Schweiger, Brunhilde
    Madrid, Lola
    Thomas, Elizabeth
    Lanaspa, Miguel
    Nohynek, Hanna
    Nokes, James
    Werner, Marta
    Danhg, Anh
    Chadha, Mandeep
    Puig-Barberà, Joan
    Caballero, Mauricio T.
    Mathisen, Maria
    Walaza, Sibongile
    Hellferscee, Orienka
    Laubscher, Matt
    Higdon, Melissa M.
    Haddix, Meredith
    Sawatwong, Pongpun
    Baggett, Henry C.
    Seidenberg, Phil
    Mwanayanda, Lawrence
    Antonio, Martin
    Ebruke, Bernard E.
    Adams, Tanja
    Rahman, Mustafizur
    Rahman, Mohammed Ziaur
    Sow, Samboa O.
    Baillie, Vicky L.
    Workman, Lesley
    Toizumi, Michiko
    Tapia, Milagritos D.
    Nguyen, Thi hien anh
    Morpeth, Susan
    Show allShow less

    Date
    2020-11-26
    Journal
    Lancet Global Health
    Publisher
    Elsevier Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/S2214-109X(20)30393-4
    Abstract
    Background: Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed vaccines or drugs exist for human metapneumovirus infections. We aimed to estimate the age-stratified human metapneumovirus-associated ALRI global incidence, hospital admissions, and mortality burden in children younger than 5 years. Methods: We estimated the global burden of human metapneumovirus-associated ALRIs in children younger than 5 years from a systematic review of 119 studies published between Jan 1, 2001, and Dec 31, 2019, and a further 40 high quality unpublished studies. We assessed risk of bias using a modified Newcastle-Ottawa Scale. We estimated incidence, hospital admission rates, and in-hospital case-fatality ratios (hCFRs) of human metapneumovirus-associated ALRI using a generalised linear mixed model. We applied incidence and hospital admission rates of human metapneumovirus–associated ALRI to population estimates to yield the morbidity burden estimates by age bands and World Bank income levels. We also estimated human metapneumovirus-associated ALRI in-hospital deaths and overall human metapneumovirus-associated ALRI deaths (both in-hospital and non-hospital deaths). Additionally, we estimated human metapneumovirus-attributable ALRI cases, hospital admissions, and deaths by combining human metapneumovirus-associated burden estimates and attributable fractions of human metapneumovirus in laboratory-confirmed human metapneumovirus cases and deaths. Findings: In 2018, among children younger than 5 years globally, there were an estimated 14·2 million human metapneumovirus-associated ALRI cases (uncertainty range [UR] 10·2 million to 20·1 million), 643 000 human metapneumovirus-associated hospital admissions (UR 425 000 to 977 000), 7700 human metapneumovirus-associated in-hospital deaths (2600 to 48 800), and 16 100 overall (hospital and community) human metapneumovirus-associated ALRI deaths (5700 to 88 000). An estimated 11·1 million ALRI cases (UR 8·0 million to 15·7 million), 502 000 ALRI hospital admissions (UR 332 000 to 762 000), and 11 300 ALRI deaths (4000 to 61 600) could be causally attributed to human metapneumovirus in 2018. Around 58% of the hospital admissions were in infants under 12 months, and 64% of in-hospital deaths occurred in infants younger than 6 months, of which 79% occurred in low-income and lower-middle-income countries. Interpretation: Infants younger than 1 year have disproportionately high risks of severe human metapneumovirus infections across all World Bank income regions and all child mortality settings, similar to respiratory syncytial virus and influenza virus. Infants younger than 6 months in low-income and lower-middle-income countries are at greater risk of death from human metapneumovirus-associated ALRI than older children and those in upper-middle-income and high-income countries. Our mortality estimates demonstrate the importance of intervention strategies for infants across all settings, and warrant continued efforts to improve the outcome of human metapneumovirus-associated ALRI among young infants in low-income and lower-middle-income countries. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
    Sponsors
    Bill & Melinda Gates Foundation Innovative Medicines Initiative.
    Keyword
    Global Burden of Disease
    Metapneumovirus
    Respiratory Tract Infections
    Child
    Infant
    Infant, Newborn
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14287
    ae974a485f413a2113503eed53cd6c53
    10.1016/S2214-109X(20)30393-4
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.