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dc.contributor.authorGordon, David E
dc.contributor.authorHiatt, Joseph
dc.contributor.authorBouhaddou, Mehdi
dc.contributor.authorRezelj, Veronica V
dc.contributor.authorUlferts, Svenja
dc.contributor.authorBraberg, Hannes
dc.contributor.authorJureka, Alexander S
dc.contributor.authorObernier, Kirsten
dc.contributor.authorGuo, Jeffrey Z
dc.contributor.authorBatra, Jyoti
dc.contributor.authorKaake, Robyn M
dc.contributor.authorWeckstein, Andrew R
dc.contributor.authorOwens, Tristan W
dc.contributor.authorGupta, Meghna
dc.contributor.authorPourmal, Sergei
dc.contributor.authorTitus, Erron W
dc.contributor.authorCakir, Merve
dc.contributor.authorSoucheray, Margaret
dc.contributor.authorMcGregor, Michael
dc.contributor.authorCakir, Zeynep
dc.contributor.authorJang, Gwendolyn
dc.contributor.authorO'Meara, Matthew J
dc.contributor.authorTummino, Tia A
dc.contributor.authorZhang, Ziyang
dc.contributor.authorFoussard, Helene
dc.contributor.authorRojc, Ajda
dc.contributor.authorZhou, Yuan
dc.contributor.authorKuchenov, Dmitry
dc.contributor.authorHüttenhain, Ruth
dc.contributor.authorXu, Jiewei
dc.contributor.authorEckhardt, Manon
dc.contributor.authorSwaney, Danielle L
dc.contributor.authorFabius, Jacqueline M
dc.contributor.authorUmmadi, Manisha
dc.contributor.authorTutuncuoglu, Beril
dc.contributor.authorRathore, Ujjwal
dc.contributor.authorModak, Maya
dc.contributor.authorHaas, Paige
dc.contributor.authorHaas, Kelsey M
dc.contributor.authorNaing, Zun Zar Chi
dc.contributor.authorPulido, Ernst H
dc.contributor.authorShi, Ying
dc.contributor.authorBarrio-Hernandez, Inigo
dc.contributor.authorMemon, Danish
dc.contributor.authorPetsalaki, Eirini
dc.contributor.authorDunham, Alistair
dc.contributor.authorMarrero, Miguel Correa
dc.contributor.authorBurke, David
dc.contributor.authorKoh, Cassandra
dc.contributor.authorVallet, Thomas
dc.contributor.authorSilvas, Jesus A
dc.contributor.authorAzumaya, Caleigh M
dc.contributor.authorBillesbølle, Christian
dc.contributor.authorBrilot, Axel F
dc.contributor.authorCampbell, Melody G
dc.contributor.authorDiallo, Amy
dc.contributor.authorDickinson, Miles Sasha
dc.contributor.authorDiwanji, Devan
dc.contributor.authorHerrera, Nadia
dc.contributor.authorHoppe, Nick
dc.contributor.authorKratochvil, Huong T
dc.contributor.authorLiu, Yanxin
dc.contributor.authorMerz, Gregory E
dc.contributor.authorMoritz, Michelle
dc.contributor.authorNguyen, Henry C
dc.contributor.authorNowotny, Carlos
dc.contributor.authorPuchades, Cristina
dc.contributor.authorRizo, Alexandrea N
dc.contributor.authorSchulze-Gahmen, Ursula
dc.contributor.authorSmith, Amber M
dc.contributor.authorSun, Ming
dc.contributor.authorYoung, Iris D
dc.contributor.authorZhao, Jianhua
dc.contributor.authorAsarnow, Daniel
dc.contributor.authorBiel, Justin
dc.contributor.authorBowen, Alisa
dc.contributor.authorBraxton, Julian R
dc.contributor.authorChen, Jen
dc.contributor.authorChio, Cynthia M
dc.contributor.authorChio, Un Seng
dc.contributor.authorDeshpande, Ishan
dc.contributor.authorDoan, Loan
dc.contributor.authorFaust, Bryan
dc.contributor.authorFlores, Sebastian
dc.contributor.authorJin, Mingliang
dc.contributor.authorKim, Kate
dc.contributor.authorLam, Victor L
dc.contributor.authorLi, Fei
dc.contributor.authorLi, Junrui
dc.contributor.authorLi, Yen-Li
dc.contributor.authorLi, Yang
dc.contributor.authorLiu, Xi
dc.contributor.authorLo, Megan
dc.contributor.authorLopez, Kyle E
dc.contributor.authorMelo, Arthur A
dc.contributor.authorMoss, Frank R
dc.contributor.authorNguyen, Phuong
dc.contributor.authorPaulino, Joana
dc.contributor.authorPawar, Komal Ishwar
dc.contributor.authorPeters, Jessica K
dc.contributor.authorPospiech, Thomas H
dc.contributor.authorSafari, Maliheh
dc.contributor.authorSangwan, Smriti
dc.contributor.authorSchaefer, Kaitlin
dc.contributor.authorThomas, Paul V
dc.contributor.authorThwin, Aye C
dc.contributor.authorTrenker, Raphael
dc.contributor.authorTse, Eric
dc.contributor.authorTsui, Tsz Kin Martin
dc.contributor.authorWang, Feng
dc.contributor.authorWhitis, Natalie
dc.contributor.authorYu, Zanlin
dc.contributor.authorZhang, Kaihua
dc.contributor.authorZhang, Yang
dc.contributor.authorZhou, Fengbo
dc.contributor.authorSaltzberg, Daniel
dc.contributor.authorHodder, Anthony J
dc.contributor.authorShun-Shion, Amber S
dc.contributor.authorWilliams, Daniel M
dc.contributor.authorWhite, Kris M
dc.contributor.authorRosales, Romel
dc.contributor.authorKehrer, Thomas
dc.contributor.authorMiorin, Lisa
dc.contributor.authorMoreno, Elena
dc.contributor.authorPatel, Arvind H
dc.contributor.authorRihn, Suzannah
dc.contributor.authorKhalid, Mir M
dc.contributor.authorVallejo-Gracia, Albert
dc.contributor.authorFozouni, Parinaz
dc.contributor.authorSimoneau, Camille R
dc.contributor.authorRoth, Theodore L
dc.contributor.authorWu, David
dc.contributor.authorKarim, Mohd Anisul
dc.contributor.authorGhoussaini, Maya
dc.contributor.authorDunham, Ian
dc.contributor.authorBerardi, Francesco
dc.contributor.authorWeigang, Sebastian
dc.contributor.authorChazal, Maxime
dc.contributor.authorPark, Jisoo
dc.contributor.authorLogue, James
dc.contributor.authorMcGrath, Marisa
dc.contributor.authorWeston, Stuart
dc.contributor.authorHaupt, Robert
dc.contributor.authorHastie, C James
dc.contributor.authorElliott, Matthew
dc.contributor.authorBrown, Fiona
dc.contributor.authorBurness, Kerry A
dc.contributor.authorReid, Elaine
dc.contributor.authorDorward, Mark
dc.contributor.authorJohnson, Clare
dc.contributor.authorWilkinson, Stuart G
dc.contributor.authorGeyer, Anna
dc.contributor.authorGiesel, Daniel M
dc.contributor.authorBaillie, Carla
dc.contributor.authorRaggett, Samantha
dc.contributor.authorLeech, Hannah
dc.contributor.authorToth, Rachel
dc.contributor.authorGoodman, Nicola
dc.contributor.authorKeough, Kathleen C
dc.contributor.authorLind, Abigail L
dc.contributor.authorKlesh, Reyna J
dc.contributor.authorHemphill, Kafi R
dc.contributor.authorCarlson-Stevermer, Jared
dc.contributor.authorOki, Jennifer
dc.contributor.authorHolden, Kevin
dc.contributor.authorMaures, Travis
dc.contributor.authorPollard, Katherine S
dc.contributor.authorSali, Andrej
dc.contributor.authorAgard, David A
dc.contributor.authorCheng, Yifan
dc.contributor.authorFraser, James S
dc.contributor.authorFrost, Adam
dc.contributor.authorJura, Natalia
dc.contributor.authorKortemme, Tanja
dc.contributor.authorManglik, Aashish
dc.contributor.authorSouthworth, Daniel R
dc.contributor.authorStroud, Robert M
dc.contributor.authorAlessi, Dario R
dc.contributor.authorDavies, Paul
dc.contributor.authorFrieman, Matthew B
dc.contributor.authorIdeker, Trey
dc.contributor.authorAbate, Carmen
dc.contributor.authorJouvenet, Nolwenn
dc.contributor.authorKochs, Georg
dc.contributor.authorShoichet, Brian
dc.contributor.authorOtt, Melanie
dc.contributor.authorPalmarini, Massimo
dc.contributor.authorShokat, Kevan M
dc.contributor.authorGarcía-Sastre, Adolfo
dc.contributor.authorRassen, Jeremy A
dc.contributor.authorGrosse, Robert
dc.contributor.authorRosenberg, Oren S
dc.contributor.authorVerba, Kliment A
dc.contributor.authorBasler, Christopher F
dc.contributor.authorVignuzzi, Marco
dc.contributor.authorPeden, Andrew A
dc.contributor.authorBeltrao, Pedro
dc.contributor.authorKrogan, Nevan J
dc.date.accessioned2020-12-11T16:01:49Z
dc.date.available2020-12-11T16:01:49Z
dc.date.issued2020-12-04
dc.identifier.urihttp://hdl.handle.net/10713/14248
dc.description.abstractThe COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.en_US
dc.description.urihttps://doi.org/10.1126/science.abe9403en_US
dc.language.isoenen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.ispartofScience (New York, N.Y.)en_US
dc.rightsCopyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.en_US
dc.subject.meshSARS Virus--geneticsen_US
dc.subject.meshMiddle East Respiratory Syndrome Virus--geneticsen_US
dc.titleComparative host-coronavirus protein interaction networks reveal pan-viral disease mechanismsen_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.doi10.1126/science.abe9403
dc.identifier.pmid33060197
dc.source.volume370
dc.source.issue6521
dc.source.countryUnited States


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