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    Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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    Author
    Gordon, David E
    Hiatt, Joseph
    Bouhaddou, Mehdi
    Rezelj, Veronica V
    Ulferts, Svenja
    Braberg, Hannes
    Jureka, Alexander S
    Obernier, Kirsten
    Guo, Jeffrey Z
    Batra, Jyoti
    Kaake, Robyn M
    Weckstein, Andrew R
    Owens, Tristan W
    Gupta, Meghna
    Pourmal, Sergei
    Titus, Erron W
    Cakir, Merve
    Soucheray, Margaret
    McGregor, Michael
    Cakir, Zeynep
    Jang, Gwendolyn
    O'Meara, Matthew J
    Tummino, Tia A
    Zhang, Ziyang
    Foussard, Helene
    Rojc, Ajda
    Zhou, Yuan
    Kuchenov, Dmitry
    Hüttenhain, Ruth
    Xu, Jiewei
    Eckhardt, Manon
    Swaney, Danielle L
    Fabius, Jacqueline M
    Ummadi, Manisha
    Tutuncuoglu, Beril
    Rathore, Ujjwal
    Modak, Maya
    Haas, Paige
    Haas, Kelsey M
    Naing, Zun Zar Chi
    Pulido, Ernst H
    Shi, Ying
    Barrio-Hernandez, Inigo
    Memon, Danish
    Petsalaki, Eirini
    Dunham, Alistair
    Marrero, Miguel Correa
    Burke, David
    Koh, Cassandra
    Vallet, Thomas
    Silvas, Jesus A
    Azumaya, Caleigh M
    Billesbølle, Christian
    Brilot, Axel F
    Campbell, Melody G
    Diallo, Amy
    Dickinson, Miles Sasha
    Diwanji, Devan
    Herrera, Nadia
    Hoppe, Nick
    Kratochvil, Huong T
    Liu, Yanxin
    Merz, Gregory E
    Moritz, Michelle
    Nguyen, Henry C
    Nowotny, Carlos
    Puchades, Cristina
    Rizo, Alexandrea N
    Schulze-Gahmen, Ursula
    Smith, Amber M
    Sun, Ming
    Young, Iris D
    Zhao, Jianhua
    Asarnow, Daniel
    Biel, Justin
    Bowen, Alisa
    Braxton, Julian R
    Chen, Jen
    Chio, Cynthia M
    Chio, Un Seng
    Deshpande, Ishan
    Doan, Loan
    Faust, Bryan
    Flores, Sebastian
    Jin, Mingliang
    Kim, Kate
    Lam, Victor L
    Li, Fei
    Li, Junrui
    Li, Yen-Li
    Li, Yang
    Liu, Xi
    Lo, Megan
    Lopez, Kyle E
    Melo, Arthur A
    Moss, Frank R
    Nguyen, Phuong
    Paulino, Joana
    Pawar, Komal Ishwar
    Peters, Jessica K
    Pospiech, Thomas H
    Safari, Maliheh
    Sangwan, Smriti
    Schaefer, Kaitlin
    Thomas, Paul V
    Thwin, Aye C
    Trenker, Raphael
    Tse, Eric
    Tsui, Tsz Kin Martin
    Wang, Feng
    Whitis, Natalie
    Yu, Zanlin
    Zhang, Kaihua
    Zhang, Yang
    Zhou, Fengbo
    Saltzberg, Daniel
    Hodder, Anthony J
    Shun-Shion, Amber S
    Williams, Daniel M
    White, Kris M
    Rosales, Romel
    Kehrer, Thomas
    Miorin, Lisa
    Moreno, Elena
    Patel, Arvind H
    Rihn, Suzannah
    Khalid, Mir M
    Vallejo-Gracia, Albert
    Fozouni, Parinaz
    Simoneau, Camille R
    Roth, Theodore L
    Wu, David
    Karim, Mohd Anisul
    Ghoussaini, Maya
    Dunham, Ian
    Berardi, Francesco
    Weigang, Sebastian
    Chazal, Maxime
    Park, Jisoo
    Logue, James
    McGrath, Marisa
    Weston, Stuart
    Haupt, Robert
    Hastie, C James
    Elliott, Matthew
    Brown, Fiona
    Burness, Kerry A
    Reid, Elaine
    Dorward, Mark
    Johnson, Clare
    Wilkinson, Stuart G
    Geyer, Anna
    Giesel, Daniel M
    Baillie, Carla
    Raggett, Samantha
    Leech, Hannah
    Toth, Rachel
    Goodman, Nicola
    Keough, Kathleen C
    Lind, Abigail L
    Klesh, Reyna J
    Hemphill, Kafi R
    Carlson-Stevermer, Jared
    Oki, Jennifer
    Holden, Kevin
    Maures, Travis
    Pollard, Katherine S
    Sali, Andrej
    Agard, David A
    Cheng, Yifan
    Fraser, James S
    Frost, Adam
    Jura, Natalia
    Kortemme, Tanja
    Manglik, Aashish
    Southworth, Daniel R
    Stroud, Robert M
    Alessi, Dario R
    Davies, Paul
    Frieman, Matthew B
    Ideker, Trey
    Abate, Carmen
    Jouvenet, Nolwenn
    Kochs, Georg
    Shoichet, Brian
    Ott, Melanie
    Palmarini, Massimo
    Shokat, Kevan M
    García-Sastre, Adolfo
    Rassen, Jeremy A
    Grosse, Robert
    Rosenberg, Oren S
    Verba, Kliment A
    Basler, Christopher F
    Vignuzzi, Marco
    Peden, Andrew A
    Beltrao, Pedro
    Krogan, Nevan J
    Show allShow less

    Date
    2020-12-04
    Journal
    Science (New York, N.Y.)
    Publisher
    American Association for the Advancement of Science
    Type
    Article
    Other
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1126/science.abe9403
    Abstract
    The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.
    Rights/Terms
    Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
    Keyword
    SARS Virus--genetics
    Middle East Respiratory Syndrome Virus--genetics
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14248
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.abe9403
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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