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dc.contributor.authorHonarpisheh, Pedram
dc.contributor.authorLee, Juneyoung
dc.contributor.authorBanerjee, Anik
dc.contributor.authorBlasco-Conesa, Maria P
dc.contributor.authorHonarpisheh, Parisa
dc.contributor.authord'Aigle, John
dc.contributor.authorMamun, Abdullah A
dc.contributor.authorRitzel, Rodney M
dc.contributor.authorChauhan, Anjali
dc.contributor.authorGanesh, Bhanu P
dc.contributor.authorMcCullough, Louise D
dc.date.accessioned2020-12-07T21:39:43Z
dc.date.available2020-12-07T21:39:43Z
dc.date.issued2020-12-01
dc.identifier.urihttp://hdl.handle.net/10713/14204
dc.description.abstractWe demonstrate that Tmem119 and P2RY12 expression is evident within both CD45int and CD45high myeloid populations in models of stroke, CAA, and aging. Interestingly, LPS stimulation of FACS-sorted adult microglia suggested that these brain-resident myeloid cells can upregulate CD45 and downregulate Tmem119 and P2RY12, making them indistinguishable from peripherally derived myeloid populations. Importantly, our findings show that these changes in the molecular signatures of microglia can occur without a contribution from the other brain-resident or peripherally sourced immune cells.en_US
dc.description.urihttps://doi.org/10.1186/s12974-020-02019-5en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofJournal of Neuroinflammationen_US
dc.subjectAgingen_US
dc.subjectBrain infiltrating myeloid cellsen_US
dc.subjectCD45en_US
dc.subjectCerebral amyloid angiopathyen_US
dc.subjectMicrogliaen_US
dc.subjectNeuroinflammationen_US
dc.subjectP2RY12en_US
dc.subjectStrokeen_US
dc.subjectTmem119en_US
dc.titlePotential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.en_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12974-020-02019-5
dc.identifier.pmid33261619
dc.source.volume17
dc.source.issue1
dc.source.beginpage366
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland


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