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    Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.

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    Author
    Honarpisheh, Pedram
    Lee, Juneyoung
    Banerjee, Anik
    Blasco-Conesa, Maria P
    Honarpisheh, Parisa
    d'Aigle, John
    Mamun, Abdullah A
    Ritzel, Rodney M
    Chauhan, Anjali
    Ganesh, Bhanu P
    McCullough, Louise D
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    Date
    2020-12-01
    Journal
    Journal of Neuroinflammation
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12974-020-02019-5
    Abstract
    We demonstrate that Tmem119 and P2RY12 expression is evident within both CD45int and CD45high myeloid populations in models of stroke, CAA, and aging. Interestingly, LPS stimulation of FACS-sorted adult microglia suggested that these brain-resident myeloid cells can upregulate CD45 and downregulate Tmem119 and P2RY12, making them indistinguishable from peripherally derived myeloid populations. Importantly, our findings show that these changes in the molecular signatures of microglia can occur without a contribution from the other brain-resident or peripherally sourced immune cells.
    Keyword
    Aging
    Brain infiltrating myeloid cells
    CD45
    Cerebral amyloid angiopathy
    Microglia
    Neuroinflammation
    P2RY12
    Stroke
    Tmem119
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14204
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12974-020-02019-5
    Scopus Count
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    UMB Open Access Articles 2020

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