Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
Blasco-Conesa, Maria P
Mamun, Abdullah A
Ritzel, Rodney M
Ganesh, Bhanu P
McCullough, Louise D
JournalJournal of Neuroinflammation
MetadataShow full item record
AbstractWe demonstrate that Tmem119 and P2RY12 expression is evident within both CD45int and CD45high myeloid populations in models of stroke, CAA, and aging. Interestingly, LPS stimulation of FACS-sorted adult microglia suggested that these brain-resident myeloid cells can upregulate CD45 and downregulate Tmem119 and P2RY12, making them indistinguishable from peripherally derived myeloid populations. Importantly, our findings show that these changes in the molecular signatures of microglia can occur without a contribution from the other brain-resident or peripherally sourced immune cells.
Brain infiltrating myeloid cells
Cerebral amyloid angiopathy
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/14204