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    Analgesia and Sedation Strategies in Mechanically Ventilated Adults with COVID-19.

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    Author
    Adams, Christopher D
    Altshuler, Jerry
    Barlow, Brooke L
    Dixit, Deepali
    Droege, Christopher A
    Effendi, Muhammad K
    Heavner, Mojdeh S
    Johnston, Jackie P
    Kiskaddon, Amy L
    Lemieux, Diana G
    Lemieux, Steven M
    Littlefield, Audrey J
    Owusu, Kent A
    Rouse, Ginger E
    Thompson Bastin, Melissa L
    Berger, Karen
    Show allShow less

    Date
    2020-10-17
    Journal
    Pharmacotherapy
    Publisher
    Pharmacotherapy Publications Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/phar.2471
    Abstract
    Evidence-based management of analgesia and sedation in COVID-19-associated acute respiratory distress syndrome remains limited. Non-guideline recommended analgesic and sedative medication regimens and deeper sedation targets have been employed for patients with COVID-19 due to exaggerated analgesia and sedation requirements with extended durations of mechanical ventilation. This, coupled with a desire to minimize nurse entry into COVID-19 patient rooms, marked obesity, altered end-organ function, and evolving medication shortages, presents numerous short- and long-term challenges. Alternative analgesic and sedative agents and regimens may pose safety risks and require judicious bedside management for appropriate use. The purpose of this commentary is to provide considerations and solutions for designing safe and effective analgesia and sedation strategies for adult patients with considerable ventilator dyssynchrony and sedation requirements, such as COVID-19.
    Rights/Terms
    © 2020 Pharmacotherapy Publications, Inc.
    Keyword
    COVID-19
    analgesia
    pharmacology
    sedation
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14202
    ae974a485f413a2113503eed53cd6c53
    10.1002/phar.2471
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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