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    cAMP levels regulate macrophage alternative activation marker expression

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    Author
    Polumuri, Swamy
    Perkins, Darren J
    Vogel, Stefanie N
    Date
    2020-11-26
    Journal
    Innate Immunity
    Publisher
    SAGE Publications Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1177/1753425920975082
    Abstract
    The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved in vitro in response to IL-4/IL-13 and results in the transcriptional up-regulation of a constellation of characteristic M2 marker genes. In vivo, additional signals from the inflammatory milieu can further increase or decrease M2 marker expression. Particularly, activation of cAMP-generating G protein-coupled receptors is reported to increase M2 markers, but whether this is strictly dependent upon cAMP production is unclear. We report herein that increased cAMP alone can increase IL-4-dependent M2 marker expression through a PKA/C/EBPβ/CREB dependent pathway in murine macrophages.
    Keyword
    Adenylate cyclase
    IL-4
    M2 macrophages
    alternative activation
    cAMP
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14200
    ae974a485f413a2113503eed53cd6c53
    10.1177/1753425920975082
    Scopus Count
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    UMB Open Access Articles 2020

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