cAMP levels regulate macrophage alternative activation marker expression
Date
2020-11-26Journal
Innate ImmunityPublisher
SAGE Publications Inc.Type
Article
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The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved in vitro in response to IL-4/IL-13 and results in the transcriptional up-regulation of a constellation of characteristic M2 marker genes. In vivo, additional signals from the inflammatory milieu can further increase or decrease M2 marker expression. Particularly, activation of cAMP-generating G protein-coupled receptors is reported to increase M2 markers, but whether this is strictly dependent upon cAMP production is unclear. We report herein that increased cAMP alone can increase IL-4-dependent M2 marker expression through a PKA/C/EBPβ/CREB dependent pathway in murine macrophages.Identifier to cite or link to this item
http://hdl.handle.net/10713/14200ae974a485f413a2113503eed53cd6c53
10.1177/1753425920975082
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