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dc.contributor.authorFagerli, K
dc.contributor.authorOmore, R
dc.contributor.authorKim, S
dc.contributor.authorOchieng, J B
dc.contributor.authorAyers, T L
dc.contributor.authorJuma, J
dc.contributor.authorFarag, T H
dc.contributor.authorNasrin, D
dc.contributor.authorPanchalingam, S
dc.contributor.authorRobins-Browne, R M
dc.contributor.authorNataro, J P
dc.contributor.authorKotloff, K L
dc.contributor.authorLevine, M M
dc.contributor.authorOundo, J
dc.contributor.authorParsons, M B
dc.contributor.authorLaserson, K F
dc.contributor.authorMintz, E D
dc.contributor.authorBreiman, R F
dc.contributor.authorO'Reilly, C E
dc.date.accessioned2020-12-07T20:21:13Z
dc.date.available2020-12-07T20:21:13Z
dc.date.issued2020-11-16
dc.identifier.urihttp://hdl.handle.net/10713/14195
dc.description.abstractTypical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study (GEMS) examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex PCR for gene targets of tEPEC. Demographic, clinical, and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008-2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio [aOR]: 2.08, 95% CI: 1.37-3.17), and convulsions (aOR: 2.83, 95% CI: 1.12-7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR: 2.2, 95% CI: 1.3-3.6) and wasted (OR: 2.5, 95%CI: 1.3-4.6). Among MSD cases, tEPEC was associated with mortality (aOR: 2.85, 95% CI: 1.47-5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised, and implemented.en_US
dc.description.urihttps://doi.org/10.1017/S0950268820002794en_US
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofEpidemiology and Infectionen_US
dc.subject.meshEnteropathogenic Escherichia colien_US
dc.subject.meshDiarrheaen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshInfanten_US
dc.subject.meshKenyaen_US
dc.titleFactors associated with typical enteropathogenic infection among children <5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008-2012en_US
dc.typeArticleen_US
dc.identifier.doi10.1017/S0950268820002794
dc.identifier.pmid33190663
dc.source.beginpage1
dc.source.endpage37
dc.source.countryEngland


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