Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection
Author
Adebamowo, Sally NAdeyemo, Adebowale A
Rotimi, Charles N
Olaniyan, Olayinka
Offiong, Richard
Adebamowo, Clement A
Date
2020-11-23Journal
BMC medical geneticsPublisher
Springer NatureType
Article
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Participants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF10/LiPA25. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) and imputation was done using the African Genome Resources Haplotype Reference Panel. Association analysis was done for hrHPV infection (125 cases/392 controls) and for persistent hrHPV infection (51 cases/355 controls) under additive genetic models adjusted for age, HIV status and the first principal component (PC) of the genotypes.Identifier to cite or link to this item
http://hdl.handle.net/10713/14192ae974a485f413a2113503eed53cd6c53
10.1186/s12881-020-01156-1
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