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    Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection

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    Author
    Adebamowo, Sally N
    Adeyemo, Adebowale A
    Rotimi, Charles N
    Olaniyan, Olayinka
    Offiong, Richard
    Adebamowo, Clement A
    Date
    2020-11-23
    Journal
    BMC medical genetics
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12881-020-01156-1
    Abstract
    Participants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF10/LiPA25. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) and imputation was done using the African Genome Resources Haplotype Reference Panel. Association analysis was done for hrHPV infection (125 cases/392 controls) and for persistent hrHPV infection (51 cases/355 controls) under additive genetic models adjusted for age, HIV status and the first principal component (PC) of the genotypes.
    Keyword
    HPV
    Cervix Uteri
    Genome-Wide Association Study
    Nigeria
    Papillomavirus Infections
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14192
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12881-020-01156-1
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