Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection
AuthorAdebamowo, Sally N
Adeyemo, Adebowale A
Rotimi, Charles N
Adebamowo, Clement A
JournalBMC medical genetics
MetadataShow full item record
AbstractParticipants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF10/LiPA25. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) and imputation was done using the African Genome Resources Haplotype Reference Panel. Association analysis was done for hrHPV infection (125 cases/392 controls) and for persistent hrHPV infection (51 cases/355 controls) under additive genetic models adjusted for age, HIV status and the first principal component (PC) of the genotypes.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/14192
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