Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection
Author
Song, HongshuoBose, Meera
Pinyakorn, Suteeraporn
Sanders-Buell, Eric
O’Sullivan, Anne Marie
Silas, Daniel
Trichavaroj, Rapee
Nuntapinit, Bessara
Pham, Phuc T.
Akapirat, Siriwat
Kroon, Eugène
de Souza, Mark
Gramzinski, Robert
Michael, Nelson L.
Robb, Merlin L.
Vasan, Sandhya
Tovanabutra, Sodsai
Ananworanich, Jintanat
Date
2020-10-01Journal
Open Forum Infectious DiseasesPublisher
Oxford University PressType
Article
Metadata
Show full item recordAbstract
We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.Identifier to cite or link to this item
http://hdl.handle.net/10713/14187ae974a485f413a2113503eed53cd6c53
10.1093/ofid/ofaa429