Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection

Author
Song, Hongshuo
Bose, Meera
Pinyakorn, Suteeraporn
Sanders-Buell, Eric
O’Sullivan, Anne Marie
Silas, Daniel
Trichavaroj, Rapee
Nuntapinit, Bessara
Pham, Phuc T.
Akapirat, Siriwat
Date
2020-10-01
Journal
Open Forum Infectious Diseases
Publisher
Oxford University Press
Type
Article

Metadata
Show full item record
See at
https://doi.org/10.1093/ofid/ofaa429
Abstract
We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
Keyword
Acute HIV infection
Fiebig stage
Genetic diversity
HIV
Identifier to cite or link to this item
http://hdl.handle.net/10713/14187
Collections