Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection
O’Sullivan, Anne Marie
Pham, Phuc T.
de Souza, Mark
Michael, Nelson L.
Robb, Merlin L.
JournalOpen Forum Infectious Diseases
PublisherOxford University Press
MetadataShow full item record
AbstractWe analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/14187