Show simple item record

dc.contributor.authorChien, Jui-Hong
dc.contributor.authorColloca, Luana
dc.contributor.authorKorzeniewska, Anna
dc.contributor.authorMeeker, Timothy J
dc.contributor.authorBienvenu, O Joe
dc.contributor.authorSaffer, Mark I
dc.contributor.authorLenz, Fred A
dc.date.accessioned2020-12-03T19:47:37Z
dc.date.available2020-12-03T19:47:37Z
dc.date.issued2020-11-26
dc.identifier.urihttp://hdl.handle.net/10713/14174
dc.description.abstractAnxiety disorders impose substantial costs upon public health and productivity in the USA and worldwide. At present, these conditions are quantified by self-report questionnaires that only apply to behaviors that are accessible to consciousness, or by the timing of responses to fear-and anxiety-related words that are indirect since they do not produce fear, e.g., Dot Probe Test and emotional Stroop. We now review the conditioned responses (CRs) to fear produced by a neutral stimulus (conditioned stimulus CS+) when it cues a painful laser unconditioned stimulus (US). These CRs include autonomic (Skin Conductance Response) and ratings of the CS+ unpleasantness, ability to command attention, and the recognition of the association of CS+ with US (expectancy). These CRs are directly related to fear, and some measure behaviors that are minimally accessible to consciousness e.g., economic scales. Fear-related CRs include non-phase-locked phase changes in oscillatory EEG power defined by frequency and time post-stimulus over baseline, and changes in phase-locked visual and laser evoked responses both of which include late potentials reflecting attention or expectancy, like the P300, or contingent negative variation. Increases (ERS) and decreases (ERD) in oscillatory power post-stimulus may be generalizable given their consistency across healthy subjects. ERS and ERD are related to the ratings above as well as to anxious personalities and clinical anxiety and can resolve activity over short time intervals like those for some moods and emotions. These results could be incorporated into an objective instrumented test that measures EEG and CRs of autonomic activity and psychological ratings related to conditioned fear, some of which are subliminal. As in the case of instrumented tests of vigilance, these results could be useful for the direct, objective measurement of multiple aspects of the risk, diagnosis, and monitoring of therapies for anxiety disorders and anxious personalities.en_US
dc.description.urihttps://doi.org/10.3390/s20236751en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofSensors (Basel, Switzerland)en_US
dc.subjectEvent Related Potentialen_US
dc.subjectEvent Related Spectral Perturbationen_US
dc.subjectanxietyen_US
dc.subjectexpectationen_US
dc.subjectfearen_US
dc.subjectfear conditioningen_US
dc.subjecthumanen_US
dc.subjectscalp EEGen_US
dc.titleBehavioral, Physiological and EEG Activities Associated with Conditioned Fear as Sensors for Fear and Anxietyen_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.doi10.3390/s20236751
dc.identifier.pmid33255916
dc.source.volume20
dc.source.issue23
dc.source.countryUnited States
dc.source.countrySwitzerland


This item appears in the following Collection(s)

Show simple item record