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dc.contributor.authorClaeys, Kimberly C
dc.contributor.authorHeil, Emily L
dc.contributor.authorHitchcock, Stephanie
dc.contributor.authorJohnson, J Kristie
dc.contributor.authorLeekha, Surbhi
dc.date.accessioned2020-12-03T19:38:56Z
dc.date.available2020-12-03T19:38:56Z
dc.date.issued2020-09-12
dc.identifier.urihttp://hdl.handle.net/10713/14172
dc.description.abstractEight-hundred thirty-two patients were included; 237 pre-RDT/AMS vs 308 post-RDT/pre-AMS vs 237 post-RDT/AMS, respectively. The proportion of patients on optimal antibiotic therapy increased with each intervention (66.5% vs 78.9% vs 83.2%; P < .0001). Time to optimal therapy (interquartile range) decreased with introduction of RDT: 47 (7.9-67.7) hours vs 24.9 (12.4-55.2) hours vs 26.5 (10.3-66.5) hours (P = .09). Using multivariable modeling, infectious diseases (ID) consult was an effect modifier. Within the ID consult stratum, controlling for source and ICU stay, compared with the pre-RDT/AMS group, both post-RDT/pre-AMS (adjusted hazard ratio [aHR], 1.34; 95% CI, 1.04-1.72) and post-RDT/AMS (aHR, 1.28; 95% CI, 1.01-1.64), improved time to optimal therapy. This effect was not seen in the stratum without ID consult.en_US
dc.description.urihttps://doi.org/10.1093/ofid/ofaa427en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofOpen Forum Infectious Diseasesen_US
dc.rights© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.en_US
dc.subjectantimicrobial stewardhipen_US
dc.subjectgram-negative bloodstream infectionen_US
dc.subjectrapid diagnostic testingen_US
dc.titleManagement of Gram-Negative Bloodstream Infections in the Era of Rapid Diagnostic Testing: Impact With and Without Antibiotic Stewardshipen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/ofid/ofaa427
dc.identifier.pmid33134414
dc.source.volume7
dc.source.issue10
dc.source.beginpageofaa427
dc.source.endpage
dc.source.countryUnited States


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