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dc.contributor.authorChiappelli, Joshua
dc.contributor.authorQuinton, Maria S
dc.contributor.authorVolfson, Dmitri
dc.contributor.authorCwik, Michael
dc.contributor.authorMarshall, Wyatt
dc.contributor.authorBruce, Heather
dc.contributor.authorGoldwaser, Eric
dc.contributor.authorKvarta, Mark
dc.contributor.authorSummerfelt, Ann
dc.contributor.authorKochunov, Peter
dc.contributor.authorO'Donnell, Patricio
dc.contributor.authorHong, Liyi Elliot
dc.date.accessioned2020-12-01T20:41:46Z
dc.date.available2020-12-01T20:41:46Z
dc.date.issued2020-11-20
dc.identifier.issn2334-265X
dc.identifier.urihttp://hdl.handle.net/10713/14162
dc.description.abstractPlasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a promising biomarker for psychiatric and neurologic disorders that impact brain structure. We hypothesized that, as schizophrenia patients have widely reported gray and white matter deficits, they would have abnormal levels of plasma 24S-hydroxycholesterol, and that plasma levels of 24S-hydroxycholesterol would be associated with brain structural and functional biomarkers for schizophrenia. Plasma levels of 24S-hydroxycholesterol were measured in 226 individuals with schizophrenia and 204 healthy controls. The results showed that levels of 24S-hydroxycholesterol were not significantly different between patients and controls. Age was significantly and negatively correlated with 24S-hydroxycholesterol in both groups, and in both groups, females had significantly higher levels of 24S-hydroxycholesterol compared to males. Levels of 24S-hydroxycholesterol were not related to average fractional anisotropy of white matter or cortical thickness, or to cognitive deficits in schizophrenia. Based on these results from a large sample and using multiple brain biomarkers, we conclude there is little to no value of plasma 24S-hydroxycholesterol as a brain metabolite biomarker for schizophrenia.en_US
dc.description.urihttps://doi.org/10.1038/s41537-020-00121-4en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNPJ schizophreniaen_US
dc.subjectplasma 24S-hydroxycholesterolen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshBrainen_US
dc.subject.meshCholesterolen_US
dc.subject.meshSchizophreniaen_US
dc.titleAssessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophreniaen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41537-020-00121-4
dc.source.volume6
dc.source.issue1
dc.source.beginpage34
dc.source.endpage
dc.source.countryUnited States


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