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    Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia

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    Author
    Chiappelli, Joshua
    Quinton, Maria S
    Volfson, Dmitri
    Cwik, Michael
    Marshall, Wyatt
    Bruce, Heather
    Goldwaser, Eric
    Kvarta, Mark
    Summerfelt, Ann
    Kochunov, Peter
    O'Donnell, Patricio
    Hong, Liyi Elliot
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    Date
    2020-11-20
    Journal
    NPJ schizophrenia
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41537-020-00121-4
    Abstract
    Plasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a promising biomarker for psychiatric and neurologic disorders that impact brain structure. We hypothesized that, as schizophrenia patients have widely reported gray and white matter deficits, they would have abnormal levels of plasma 24S-hydroxycholesterol, and that plasma levels of 24S-hydroxycholesterol would be associated with brain structural and functional biomarkers for schizophrenia. Plasma levels of 24S-hydroxycholesterol were measured in 226 individuals with schizophrenia and 204 healthy controls. The results showed that levels of 24S-hydroxycholesterol were not significantly different between patients and controls. Age was significantly and negatively correlated with 24S-hydroxycholesterol in both groups, and in both groups, females had significantly higher levels of 24S-hydroxycholesterol compared to males. Levels of 24S-hydroxycholesterol were not related to average fractional anisotropy of white matter or cortical thickness, or to cognitive deficits in schizophrenia. Based on these results from a large sample and using multiple brain biomarkers, we conclude there is little to no value of plasma 24S-hydroxycholesterol as a brain metabolite biomarker for schizophrenia.
    Keyword
    plasma 24S-hydroxycholesterol
    Biomarkers
    Brain
    Cholesterol
    Schizophrenia
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14162
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41537-020-00121-4
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