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    Atopic dermatitis as a multifactorial skin disorder. Can the analysis of pathophysiological targets represent the winning therapeutic strategy?

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    Author
    Magnifico, Irene
    Petronio, Giulio Petronio
    Venditti, Noemi
    Cutuli, Marco Alfio
    Pietrangelo, Laura
    Vergalito, Franca
    Mangano, Katia
    Zella, Davide
    Di Marco, Roberto
    Date
    2020-11-01
    Journal
    Pharmaceuticals
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/ph13110411
    Abstract
    Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be considered as the two main factors involved in this pathological skin condition. The loss of the skin barrier function is often linked to dysbiosis and immunological dysfunction, with an imbalance in the ratio between the pathogen Staphylococcus aureus and/or other microorganisms residing in the skin. The bibliographic research was conducted on PubMed, using the following keywords: ‘atopic dermatitis’, ‘bacterial therapy’, ‘drug delivery system’ and ‘alternative therapy’. The main studies concerning microbial therapy, such as the use of bacteria and/or part thereof with microbiota transplantation, and drug delivery systems to recover skin barrier function have been summarized. The studies examined show great potential in the development of effective therapeutic strategies for AD and AD-like symptoms. Despite this promise, however, future investigative efforts should focus both on the replication of some of these studies on a larger scale, with clinical and demographic characteristics that reflect the general AD population, and on the process of standardisation, in order to produce reliable data.
    Keyword
    Atopic dermatitis
    Cutaneous dysbiosis
    Drug delivery systems
    Microbial therapy
    Skin barrier
    Staphylococcus aureus
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14150
    ae974a485f413a2113503eed53cd6c53
    10.3390/ph13110411
    Scopus Count
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