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dc.contributor.authorChatree, Saimai
dc.contributor.authorThongmaen, Nanthaphop
dc.contributor.authorTantivejkul, Kwanchanit
dc.contributor.authorSitticharoon, Chantacha
dc.contributor.authorVucenik, Ivana
dc.date.accessioned2020-11-16T16:11:09Z
dc.date.available2020-11-16T16:11:09Z
dc.date.issued2020-11-01
dc.identifier.urihttp://hdl.handle.net/10713/14083
dc.description.abstractRecently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. Although their roles in cancer treatment and prevention have been extensively reported, interestingly, they may also have distinctive properties in energy metabolism and metabolic disorders. We review inositols and inositol phosphate metabolism in mammalian cells to establish their biological activities and highlight their potential roles in energy metabolism. These molecules are known to decrease insulin resistance, increase insulin sensitivity, and have diverse properties with importance from cell signaling to metabolism. Evidence showed that inositol phosphates might enhance the browning of white adipocytes and directly improve insulin sensitivity through adipocytes. In addition, inositol pyrophosphates containing high-energy phosphate bonds are considered in increasing cellular energetics. Despite all recent advances, many aspects of the bioactivity of inositol phosphates are still not clear, especially their effects on insulin resistance and alteration of metabolism, so more research is needed.en_US
dc.description.urihttps://doi.org/10.3390/molecules25215079en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMolecules (Basel, Switzerland)en_US
dc.subjectIP6en_US
dc.subjectenergy metabolismen_US
dc.subjectinositol phosphatesen_US
dc.subjectinsulin resistanceen_US
dc.subjectmyo-inositolen_US
dc.titleRole of Inositols and Inositol Phosphates in Energy Metabolismen_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.doi10.3390/molecules25215079
dc.identifier.pmid33139672
dc.source.volume25
dc.source.issue21
dc.source.countrySwitzerland


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