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dc.contributor.authorNdembi, Nicaise
dc.contributor.authorMurtala-Ibrahim, Fati
dc.contributor.authorTola, Monday
dc.contributor.authorJumare, Jibreel
dc.contributor.authorAliyu, Ahmad
dc.contributor.authorAlabi, Peter
dc.contributor.authorMensah, Charles
dc.contributor.authorAbimiku, Alash'le
dc.contributor.authorQuiñones-Mateu, Miguel E
dc.contributor.authorCrowell, Trevor A
dc.contributor.authorRhee, Soo-Yon
dc.contributor.authorShafer, Robert W
dc.contributor.authorGupta, Ravindra
dc.contributor.authorBlattner, William
dc.contributor.authorCharurat, Manhattan E
dc.contributor.authorDakum, Patrick
dc.date.accessioned2020-11-09T20:28:03Z
dc.date.available2020-11-09T20:28:03Z
dc.date.issued2020-11-03
dc.identifier.urihttp://hdl.handle.net/10713/14061
dc.description.abstractA retrospective cohort study was conducted at the University of Abuja Teaching Hospital, a tertiary health care facility, using data from February 2005 to December 2014 in Abuja, Nigeria. All PLWH aged ≥ 15 years who initiated ART with at least 6-month follow-up and one CD4 measurement were included. Immunologic failure was defined as a CD4 decrease to or below pre-ART level or persistent CD4 < 100 cells per mm3 after 6 months on ART. Virologic failure (VF) was defined as two consecutive HIV-1 RNA levels > 1000 copies/mL after at least 6 months of ART and enhanced adherence counselling. HIV drug resistance (Sanger sequences) was analyzed using the Stanford HIV database algorithm and scored for resistance to common nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Univariate and multivariate log binomial regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs).en_US
dc.description.urihttps://doi.org/10.1186/s12981-020-00317-9en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofAIDS Research and Therapyen_US
dc.subjectfirst-line treatment failureen_US
dc.subjectHIV/AIDSen_US
dc.subjectpredictorsen_US
dc.subject.meshAntiretroviral Therapy, Highly Activeen_US
dc.subject.meshNigeriaen_US
dc.titlePredictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeriaen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12981-020-00317-9
dc.identifier.pmid33143751
dc.source.volume17
dc.source.issue1
dc.source.beginpage64
dc.source.endpage
dc.source.countryEngland


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