Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria
Author
Ndembi, NicaiseMurtala-Ibrahim, Fati
Tola, Monday
Jumare, Jibreel
Aliyu, Ahmad
Alabi, Peter
Mensah, Charles
Abimiku, Alash'le
Quiñones-Mateu, Miguel E
Crowell, Trevor A
Rhee, Soo-Yon
Shafer, Robert W
Gupta, Ravindra
Blattner, William
Charurat, Manhattan E
Dakum, Patrick
Date
2020-11-03Journal
AIDS Research and TherapyPublisher
Springer NatureType
Article
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A retrospective cohort study was conducted at the University of Abuja Teaching Hospital, a tertiary health care facility, using data from February 2005 to December 2014 in Abuja, Nigeria. All PLWH aged ≥ 15 years who initiated ART with at least 6-month follow-up and one CD4 measurement were included. Immunologic failure was defined as a CD4 decrease to or below pre-ART level or persistent CD4 < 100 cells per mm3 after 6 months on ART. Virologic failure (VF) was defined as two consecutive HIV-1 RNA levels > 1000 copies/mL after at least 6 months of ART and enhanced adherence counselling. HIV drug resistance (Sanger sequences) was analyzed using the Stanford HIV database algorithm and scored for resistance to common nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Univariate and multivariate log binomial regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs).Identifier to cite or link to this item
http://hdl.handle.net/10713/14061ae974a485f413a2113503eed53cd6c53
10.1186/s12981-020-00317-9
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