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    Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria

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    Author
    Ndembi, Nicaise
    Murtala-Ibrahim, Fati
    Tola, Monday
    Jumare, Jibreel
    Aliyu, Ahmad
    Alabi, Peter
    Mensah, Charles
    Abimiku, Alash'le
    Quiñones-Mateu, Miguel E
    Crowell, Trevor A
    Rhee, Soo-Yon
    Shafer, Robert W
    Gupta, Ravindra
    Blattner, William
    Charurat, Manhattan E
    Dakum, Patrick
    Show allShow less

    Date
    2020-11-03
    Journal
    AIDS Research and Therapy
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12981-020-00317-9
    Abstract
    A retrospective cohort study was conducted at the University of Abuja Teaching Hospital, a tertiary health care facility, using data from February 2005 to December 2014 in Abuja, Nigeria. All PLWH aged ≥ 15 years who initiated ART with at least 6-month follow-up and one CD4 measurement were included. Immunologic failure was defined as a CD4 decrease to or below pre-ART level or persistent CD4 < 100 cells per mm3 after 6 months on ART. Virologic failure (VF) was defined as two consecutive HIV-1 RNA levels > 1000 copies/mL after at least 6 months of ART and enhanced adherence counselling. HIV drug resistance (Sanger sequences) was analyzed using the Stanford HIV database algorithm and scored for resistance to common nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Univariate and multivariate log binomial regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs).
    Keyword
    first-line treatment failure
    HIV/AIDS
    predictors
    Antiretroviral Therapy, Highly Active
    Nigeria
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/14061
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12981-020-00317-9
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