Show simple item record

dc.contributor.authorKhan, Shahid Y
dc.contributor.authorAli, Muhammad
dc.contributor.authorLee, Mei-Chong W
dc.contributor.authorMa, Zhiwei
dc.contributor.authorBiswas, Pooja
dc.contributor.authorKhan, Asma A
dc.contributor.authorNaeem, Muhammad Asif
dc.contributor.authorRiazuddin, Saima
dc.contributor.authorRiazuddin, Sheikh
dc.contributor.authorAyyagari, Radha
dc.contributor.authorHejtmancik, J Fielding
dc.contributor.authorRiazuddin, S Amer
dc.date.accessioned2020-10-30T15:29:24Z
dc.date.available2020-10-30T15:29:24Z
dc.date.issued2020-10-13
dc.identifier.urihttp://hdl.handle.net/10713/13989
dc.description.abstractHere we report whole genome sequencing of four individuals (H3, H4, H5, and H6) from a family of Pakistani descent. Whole genome sequencing yielded 1084.92, 894.73, 1068.62, and 1005.77 million mapped reads corresponding to 162.73, 134.21, 160.29, and 150.86 Gb sequence data and 52.49x, 43.29x, 51.70x, and 48.66x average coverage for H3, H4, H5, and H6, respectively. We identified 3,529,659, 3,478,495, 3,407,895, and 3,426,862 variants in the genomes of H3, H4, H5, and H6, respectively, including 1,668,024 variants common in the four genomes. Further, we identified 42,422, 39,824, 28,599, and 35,206 novel variants in the genomes of H3, H4, H5, and H6, respectively. A major fraction of the variants identified in the four genomes reside within the intergenic regions of the genome. Single nucleotide polymorphism (SNP) genotype based comparative analysis with ethnic populations of 1000 Genomes database linked the ancestry of all four genomes with the South Asian populations, which was further supported by mitochondria based haplogroup analysis. In conclusion, we report whole genome sequencing of four individuals of Pakistani descent. © 2020, The Author(s).en_US
dc.description.urihttps://doi.org/10.1038/s41597-020-00664-2en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofScientific Dataen_US
dc.subjectPakistani descenten_US
dc.subject.meshWhole Genome Sequencingen_US
dc.subject.meshFamilyen_US
dc.titleWhole genome sequencing data of multiple individuals of Pakistani descent.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.doi10.1038/s41597-020-00664-2
dc.identifier.pmid33051442
dc.source.volume7
dc.source.issue1
dc.source.beginpage350
dc.source.endpage
dc.source.countryUnited States
dc.source.countryEngland


This item appears in the following Collection(s)

Show simple item record