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dc.contributor.authorVitale, Alessandra Maria
dc.contributor.authorSantonocito, Radha
dc.contributor.authorVergilio, Giuseppe
dc.contributor.authorGammazza, Antonella Marino
dc.contributor.authorCampanella, Claudia
dc.contributor.authorde Macario, Everly Conway
dc.contributor.authorBucchieri, Fabio
dc.contributor.authorMacario, Alberto J.L.
dc.contributor.authorBavisotto, Celeste Caruso
dc.date.accessioned2020-10-26T19:24:47Z
dc.date.available2020-10-26T19:24:47Z
dc.date.issued2020-10-01
dc.identifier.urihttp://hdl.handle.net/10713/13946
dc.description.abstractPrimary and metastatic brain tumors are usually serious conditions with poor prognosis, which reveal the urgent need of developing rapid diagnostic tools and efficacious treatments. To achieve these objectives, progress must be made in the understanding of brain tumor biology, for example, how they resist natural defenses and therapeutic intervention. One resistance mechanism involves extracellular vesicles that are released by tumors to meet target cells nearby or distant via circulation and reprogram them by introducing their cargo. This consists of different molecules among which are microRNAs (miRNAs) and molecular chaperones, the focus of this article. miRNAs modify target cells in the immune system to avoid antitumor reaction and chaperones are key survival molecules for the tumor cell. Extracellular vesicles cargo reflects the composition and metabolism of the original tumor cell; therefore, it is a source of markers, including the miRNAs and chaperones discussed in this article, with potential diagnostic and prognostic value. This and their relatively easy availability by minimally invasive procedures (e.g., drawing venous blood) illustrate the potential of extracellular vesicles as useful materials to manage brain tumor patients. Furthermore, understanding extracellular vesicles circulation and interaction with target cells will provide the basis for using this vesicle for delivering therapeutic compounds to selected tumor cells. © 2020 by the authors.en_US
dc.description.sponsorshipThis work was funded in part by the Italian National Operational Programme (PON) «Imprese e Competitività» 2014-2020 FESR, grant awarded by the Italian Ministry of Economic Development to the project titled «Gestione di un servizio integrato multicentrico di diagnostica e terapia personalizzata in oncologia» (Project code: F/090012/01-02/X36). A.J.L.M and E.C.d.M. were partially supported by IMET and IEMEST. This is IMET contribution number IMET 20-019.en_US
dc.description.urihttps://doi.org/10.3390/app10196961en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofApplied Sciences (Switzerland)en_US
dc.subjectBrain tumorsen_US
dc.subjectDiagnostic toolsen_US
dc.subjectDrug deliveryen_US
dc.subjectExtracellular vesiclesen_US
dc.subjectMiRNAen_US
dc.subjectMolecular chaperonesen_US
dc.titleBrain tumor-derived extracellular vesicles as carriers of disease markers: Molecular chaperones and micrornasen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/app10196961
dc.source.volume10
dc.source.issue19
dc.source.beginpage1
dc.source.endpage26


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