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dc.contributor.authorStauffer, Paul R
dc.contributor.authorRodrigues, Dario B
dc.contributor.authorGoldstein, Robert
dc.contributor.authorNguyen, Thinh
dc.contributor.authorYu, Yan
dc.contributor.authorWan, Shuying
dc.contributor.authorWoodward, Richard
dc.contributor.authorGibbs, Michael
dc.contributor.authorVasilchenko, Ilya L
dc.contributor.authorOsintsev, Alexey M
dc.contributor.authorBar-Ad, Voichita
dc.contributor.authorLeeper, Dennis B
dc.contributor.authorShi, Wenyin
dc.contributor.authorJudy, Kevin D
dc.contributor.authorHurwitz, Mark D
dc.date.accessioned2020-10-23T14:56:47Z
dc.date.available2020-10-23T14:56:47Z
dc.date.issued2020-10-13
dc.identifier.urihttp://hdl.handle.net/10713/13919
dc.description.abstractAim: Hyperthermia (HT) has been shown to improve clinical response to radiation therapy (RT) for cancer. Synergism is dramatically enhanced if HT and RT are combined simultaneously, but appropriate technology to apply treatments together does not exist. This study investigates the feasibility of delivering HT with RT to a 5-10mm annular rim of at-risk tissue around a tumor resection cavity using a temporary thermobrachytherapy (TBT) balloon implant. Methods: A balloon catheter was designed to deliver radiation from High Dose Rate (HDR) brachytherapy concurrent with HT delivered by filling the balloon with magnetic nanoparticles (MNP) and immersing it in a radiofrequency magnetic field. Temperature distributions in brain around the TBT balloon were simulated with temperature dependent brain blood perfusion using numerical modeling. A magnetic induction system was constructed and used to produce rapid heating (>0.2°C/s) of MNP-filled balloons in brain tissue-equivalent phantoms by absorbing 0.5 W/ml from a 5.7 kA/m field at 133 kHz. Results: Simulated treatment plans demonstrate the ability to heat at-risk tissue around a brain tumor resection cavity between 40-48°C for 2-5cm diameter balloons. Experimental thermal dosimetry verifies the expected rapid and spherically symmetric heating of brain phantom around the MNP-filled balloon at a magnetic field strength that has proven safe in previous clinical studies. Conclusions: These preclinical results demonstrate the feasibility of using a TBT balloon to deliver heat simultaneously with HDR brachytherapy to tumor bed around a brain tumor resection cavity, with significantly improved uniformity of heating over previous multi-catheter interstitial approaches. Considered along with results of previous clinical thermobrachytherapy trials, this new capability is expected to improve both survival and quality of life in patients with glioblastoma multiforme.en_US
dc.description.sponsorshipNIH R41 CA-239815en_US
dc.description.urihttps://doi.org/10.1080/02656736.2020.1829103en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Inc.en_US
dc.relation.ispartofInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncologyen_US
dc.subjectHyperthermiaen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectcanceren_US
dc.subjectnanoparticlesen_US
dc.subjectthermobrachytherapyen_US
dc.subjecttumorbed therapyen_US
dc.titleFeasibility of removable balloon implant for simultaneous magnetic nanoparticle heating and HDR brachytherapy of brain tumor resection cavities.en_US
dc.typeArticleen_US
dc.identifier.doi10.1080/02656736.2020.1829103
dc.identifier.pmid33047639
dc.source.volume37
dc.source.issue1
dc.source.beginpage1189
dc.source.endpage1201
dc.source.countryEngland


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