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    Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma

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    Author
    Pamidimukkala, Nidhi
    Puts, Gemma S.
    Leonard, M. Kathryn
    Snyder, Devin cc
    Dabernat, Sandrine
    De Fabo, Edward C.
    Noonan, Frances P.
    Slominski, Andrzej
    Merlino, Glenn
    Kaetzel, David M.
    Date
    2020-10-07
    Journal
    British Journal of Cancer
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41416-020-01096-w
    Abstract
    NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines of melanoma, breast carcinoma and other cancer origins without affecting their growth in culture or as primary tumours. Herein, we selectively ablated the tandemly arranged Nme1 and Nme2 genes to assess their individual impacts on metastatic activity in a mouse model (HGF:p16−/−) of ultraviolet radiation (UVR)-induced melanoma. Metastatic activity was strongly enhanced in both genders of Nme1- and Nme2-null mice, with stronger activity in females across all genotypes. The study ascribes MSG activity to Nme2 for the first time in an in vivo model of spontaneous cancer, as well as a novel metastasis-suppressor function to Nme1 in the specific context of UVR-induced melanoma.
    Sponsors
    U.S. Department of Veterans Affairs
    Keyword
    Nme1
    Nme2
    Genes, Tumor Suppressor--physiology
    Melanoma
    Mice
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13872
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-020-01096-w
    Scopus Count
    Collections
    UMB Open Access Articles 2020

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