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    Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness.

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    Author
    Valk, Sofie L
    Xu, Ting
    Margulies, Daniel S
    Masouleh, Shahrzad Kharabian
    Paquola, Casey
    Goulas, Alexandros
    Kochunov, Peter
    Smallwood, Jonathan
    Yeo, B T Thomas
    Bernhardt, Boris C
    Eickhoff, Simon B
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    Date
    2020-09-25
    Journal
    Science advances
    Publisher
    American Association for the Advancement of Science
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1126/sciadv.abb3417
    Abstract
    The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.
    Rights/Terms
    Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
    Keyword
    Humans
    Macaca
    Primates
    Phylogeny
    Cerebral Cortex
    Cognition
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13852
    ae974a485f413a2113503eed53cd6c53
    10.1126/sciadv.abb3417
    Scopus Count
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