Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness.
Author
Valk, Sofie LXu, Ting
Margulies, Daniel S
Masouleh, Shahrzad Kharabian
Paquola, Casey
Goulas, Alexandros
Kochunov, Peter
Smallwood, Jonathan
Yeo, B T Thomas
Bernhardt, Boris C
Eickhoff, Simon B
Date
2020-09-25Journal
Science advancesPublisher
American Association for the Advancement of ScienceType
Article
Metadata
Show full item recordAbstract
The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.Rights/Terms
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).Identifier to cite or link to this item
http://hdl.handle.net/10713/13852ae974a485f413a2113503eed53cd6c53
10.1126/sciadv.abb3417