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dc.contributor.authorPizzagalli, Fabrizio
dc.contributor.authorAuzias, Guillaume
dc.contributor.authorYang, Qifan
dc.contributor.authorMathias, Samuel R
dc.contributor.authorFaskowitz, Joshua
dc.contributor.authorBoyd, Joshua D
dc.contributor.authorAmini, Armand
dc.contributor.authorRivière, Denis
dc.contributor.authorMcMahon, Katie L
dc.contributor.authorde Zubicaray, Greig I
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMangin, Jean-François
dc.contributor.authorGlahn, David C
dc.contributor.authorBlangero, John
dc.contributor.authorWright, Margaret J
dc.contributor.authorThompson, Paul M
dc.contributor.authorKochunov, Peter
dc.contributor.authorJahanshad, Neda
dc.date.accessioned2020-09-29T15:47:32Z
dc.date.available2020-09-29T15:47:32Z
dc.date.issued2020-09-15
dc.identifier.urihttp://hdl.handle.net/10713/13788
dc.description.abstractCortical folds help drive the parcellation of the human cortex into functionally specific regions. Variations in the length, depth, width, and surface area of these sulcal landmarks have been associated with disease, and may be genetically mediated. Before estimating the heritability of sulcal variation, the extent to which these metrics can be reliably extracted from in-vivo MRI must be established. Using four independent test-retest datasets, we found high reliability across the brain (intraclass correlation interquartile range: 0.65–0.85). Heritability estimates were derived for three family-based cohorts using variance components analysis and pooled (total N > 3000); the overall sulcal heritability pattern was correlated to that derived for a large population cohort (N > 9000) calculated using genomic complex trait analysis. Overall, sulcal width was the most heritable metric, and earlier forming sulci showed higher heritability. The inter-hemispheric genetic correlations were high, yet select sulci showed incomplete pleiotropy, suggesting hemisphere-specific genetic influences.en_US
dc.description.urihttps://doi.org/10.1038/s42003-020-01163-1en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofCommunications Biologyen_US
dc.subjectcortical foldsen_US
dc.subject.lcshCerebral sulcien_US
dc.subject.meshHeredityen_US
dc.titleThe reliability and heritability of cortical folds and their genetic correlations across hemispheresen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s42003-020-01163-1
dc.identifier.pmid32934300
dc.source.volume3
dc.source.issue1
dc.source.beginpage510
dc.source.endpage
dc.source.countryEngland


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