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    The reliability and heritability of cortical folds and their genetic correlations across hemispheres

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    Author
    Pizzagalli, Fabrizio
    Auzias, Guillaume
    Yang, Qifan
    Mathias, Samuel R
    Faskowitz, Joshua
    Boyd, Joshua D
    Amini, Armand
    Rivière, Denis
    McMahon, Katie L
    de Zubicaray, Greig I
    Martin, Nicholas G
    Mangin, Jean-François
    Glahn, David C
    Blangero, John
    Wright, Margaret J
    Thompson, Paul M
    Kochunov, Peter
    Jahanshad, Neda
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    Date
    2020-09-15
    Journal
    Communications Biology
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s42003-020-01163-1
    Abstract
    Cortical folds help drive the parcellation of the human cortex into functionally specific regions. Variations in the length, depth, width, and surface area of these sulcal landmarks have been associated with disease, and may be genetically mediated. Before estimating the heritability of sulcal variation, the extent to which these metrics can be reliably extracted from in-vivo MRI must be established. Using four independent test-retest datasets, we found high reliability across the brain (intraclass correlation interquartile range: 0.65–0.85). Heritability estimates were derived for three family-based cohorts using variance components analysis and pooled (total N > 3000); the overall sulcal heritability pattern was correlated to that derived for a large population cohort (N > 9000) calculated using genomic complex trait analysis. Overall, sulcal width was the most heritable metric, and earlier forming sulci showed higher heritability. The inter-hemispheric genetic correlations were high, yet select sulci showed incomplete pleiotropy, suggesting hemisphere-specific genetic influences.
    Keyword
    cortical folds
    Cerebral sulci
    Heredity
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13788
    ae974a485f413a2113503eed53cd6c53
    10.1038/s42003-020-01163-1
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