Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H.H.; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Bernard, Manon; Bis, Joshua C.; Gillespie, Nathan A.; Luciano, Michelle; Mishra, Aniket; Scholz, Markus; Teumer, Alexander; Xia, Rui; Jian, Xueqiu; Mosley, Thomas H.; Saba, Yasaman; Pirpamer, Lukas; Seiler, Stephan; Becker, James T.; Carmichael, Owen; Rotter, Jerome I.; Psaty, Bruce M.; Lopez, Oscar L.; Amin, Najaf; van der Lee, Sven J.; Yang, Qiong; Himali, Jayandra J.; Maillard, Pauline; Beiser, Alexa S.; DeCarli, Charles; Karama, Sherif; Lewis, Lindsay; Harris, Mat; Bastin, Mark E.; Deary, Ian J.; Veronica Witte, A.; Beyer, Frauke; Loeffler, Markus; Mather, Karen A.; Schofield, Peter R.; Thalamuthu, Anbupalam; Kwok, John B.; Wright, Margaret J.; Ames, David; Trollor, Julian; Jiang, Jiyang; Brodaty, Henry; Wen, Wei; Vernooij, Meike W.; Hofman, Albert; Uitterlinden, André G.; Niessen, Wiro J.; Wittfeld, Katharina; Bülow, Robin; Völker, Uwe; Pausova, Zdenka; Bruce Pike, G.; Maingault, Sophie; Crivello, Fabrice; Tzourio, Christophe; Amouyel, Philippe; Mazoyer, Bernard; Neale, Michael C.; Franz, Carol E.; Lyons, Michael J.; Panizzon, Matthew S.; Andreassen, Ole A.; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N.; Colodro-Conde, Lucía; Bralten, Janita; Hibar, Derrek P.; Lind, Penelope A.; Pizzagalli, Fabrizio; Stein, Jason L.; Thompson, Paul M.; Medland, Sarah E.; Jahanshad, Neda; Painter, Jodie N.; Colodro-Conde, Lucía; Hibar, Derrek P.; Lind, Penelope A.; Ching, Christopher R.K.; McMahon, Mary Agnes B.; Shatokhina, Natalia; Zsembik, Leo C.P.; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.

Author

Hofer, Edith
Roshchupkin, Gennady V.
Adams, Hieab H.H.
Knol, Maria J.
Lin, Honghuang
Li, Shuo
Zare, Habil
Ahmad, Shahzad
Armstrong, Nicola J.
Satizabal, Claudia L.

Show all

Date

2020-12-01

Journal

Nature Communications

Publisher

Springer Nature

Type

Article

Metadata

Show full item record

See at

https://doi.org/10.1038/s41467-020-18367-y

Abstract

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Authors: Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kähönen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimäki T, Li SC, Lill CM, Liu T, Koini M, London E, Longstreth WT Jr, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikäinen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumaré A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hägg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Räikkönen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Dan Rujescu, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH Jr, Bressler J, Lencz T, Deary IJ
Issue date: 2018 May 29