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    Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

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    Author
    Hofer, Edith
    Roshchupkin, Gennady V.
    Adams, Hieab H.H.
    Knol, Maria J.
    Lin, Honghuang
    Li, Shuo
    Zare, Habil
    Ahmad, Shahzad
    Armstrong, Nicola J.
    Satizabal, Claudia L.
    Bernard, Manon
    Bis, Joshua C.
    Gillespie, Nathan A.
    Luciano, Michelle
    Mishra, Aniket
    Scholz, Markus
    Teumer, Alexander
    Xia, Rui
    Jian, Xueqiu
    Mosley, Thomas H.
    Saba, Yasaman
    Pirpamer, Lukas
    Seiler, Stephan
    Becker, James T.
    Carmichael, Owen
    Rotter, Jerome I.
    Psaty, Bruce M.
    Lopez, Oscar L.
    Amin, Najaf
    van der Lee, Sven J.
    Yang, Qiong
    Himali, Jayandra J.
    Maillard, Pauline
    Beiser, Alexa S.
    DeCarli, Charles
    Karama, Sherif
    Lewis, Lindsay
    Harris, Mat
    Bastin, Mark E.
    Deary, Ian J.
    Veronica Witte, A.
    Beyer, Frauke
    Loeffler, Markus
    Mather, Karen A.
    Schofield, Peter R.
    Thalamuthu, Anbupalam
    Kwok, John B.
    Wright, Margaret J.
    Ames, David
    Trollor, Julian
    Jiang, Jiyang
    Brodaty, Henry
    Wen, Wei
    Vernooij, Meike W.
    Hofman, Albert
    Uitterlinden, André G.
    Niessen, Wiro J.
    Wittfeld, Katharina
    Bülow, Robin
    Völker, Uwe
    Pausova, Zdenka
    Bruce Pike, G.
    Maingault, Sophie
    Crivello, Fabrice
    Tzourio, Christophe
    Amouyel, Philippe
    Mazoyer, Bernard
    Neale, Michael C.
    Franz, Carol E.
    Lyons, Michael J.
    Panizzon, Matthew S.
    Andreassen, Ole A.
    Dale, Anders M.
    Logue, Mark
    Grasby, Katrina L.
    Jahanshad, Neda
    Painter, Jodie N.
    Colodro-Conde, Lucía
    Bralten, Janita
    Hibar, Derrek P.
    Lind, Penelope A.
    Pizzagalli, Fabrizio
    Stein, Jason L.
    Thompson, Paul M.
    Medland, Sarah E.
    Jahanshad, Neda
    Painter, Jodie N.
    Colodro-Conde, Lucía
    Hibar, Derrek P.
    Lind, Penelope A.
    Ching, Christopher R.K.
    McMahon, Mary Agnes B.
    Shatokhina, Natalia
    Zsembik, Leo C.P.
    Agartz, Ingrid
    Alhusaini, Saud
    Almeida, Marcio A.A.
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    Date
    2020-12-01
    Journal
    Nature Communications
    Publisher
    Springer Nature
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1038/s41467-020-18367-y
    Abstract
    Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
    Sponsors
    National Heart, Lung, and Blood Institute
    Keyword
    cortical structure
    Genome-Wide Association Study
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13778
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-020-18367-y
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