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dc.contributor.authorKönig, Paul
dc.contributor.authorEckstein, Markus
dc.contributor.authorJung, Rudolf
dc.contributor.authorAbdulrahman, Amer
dc.contributor.authorGuzman, Juan
dc.contributor.authorWeigelt, Katrin
dc.contributor.authorSerrero, Ginette
dc.contributor.authorHayashi, Jun
dc.contributor.authorGeppert, Carol
dc.contributor.authorStöhr, Robert
dc.contributor.authorHartmann, Arndt
dc.contributor.authorWullich, Bernd
dc.contributor.authorWach, Sven
dc.contributor.authorTaubert, Helge
dc.contributor.authorLieb, Verena
dc.date.accessioned2020-09-22T15:36:15Z
dc.date.available2020-09-22T15:36:15Z
dc.date.issued2020-09-01
dc.identifier.urihttp://hdl.handle.net/10713/13749
dc.description.abstractProstate cancer (PCa) is the second most common cancer, causing morbidity and mortality among men world-wide. The expression of the androgen receptor (AR) and its splice variants is a crucial factor of prostate cancer biology that has not been comprehensively studied in PCa tumors. The aim of this study was to characterize the protein expression of the AR and its splice variant, AR-V7, and their subcellular distributions in PCa by immunohistochemistry and to correlate the results to the clinicopathological data and prognosis. Immunohistochemical staining for AR and AR-V7 was performed on a tissue microarray (TMA) with specimens from 410 PCa patients using an immunoreactive score (IRS) or only the percentage of AR-V7 staining in cytoplasmic granules. Nuclear or cytoplasmic AR staining was not associated with prognosis. AR-V7 staining was only occasionally observed in the nucleus. However, AR-V7 staining in the cytoplasm or in cytoplasmic granules was associated with relapse-free survival (RFS). AR-V7 staining of the cytoplasm was associated with a shorter RFS, whereas AR-V7 staining of cytoplasmic granules was associated with a longer RFS. In a multivariate Cox’s regression analysis, only negative (<5%) AR-V7 staining of cytoplasmic granules remained an independent prognostic factor for RFS (HR = 5.3; p = 0.006). In a further subgroup analysis by multivariate Cox’s regression analysis, AR-V7 was an independent prognostic factor in the following groups: age ≤ 65 (HR = 9.7; p = 0.029), negative CK20 staining (HR = 7.0; p = 0.008), and positive perineural invasion (HR = 3.7; p = 0.034). Altogether, AR-V7 protein in granular cytoplasmic structures is an independent prognostic factor for RFS in PCa patients.en_US
dc.description.sponsorshipFriedrich-Alexander-Universität Erlangen-Nürnbergen_US
dc.description.urihttps://doi.org/10.3390/cancers12092639en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofCancersen_US
dc.subjectARen_US
dc.subjectAR-V7en_US
dc.subjectGleason scoreen_US
dc.subjectPerineural invasionen_US
dc.subjectPrognosisen_US
dc.subjectProstate canceren_US
dc.subjectRelapse-free survivalen_US
dc.subjectRFSen_US
dc.titleExpression of AR-V7 (Androgen receptor variant 7) protein in granular cytoplasmic structures is an independent prognostic factor in prostate cancer patientsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cancers12092639
dc.identifier.pmid32947898
dc.source.volume12
dc.source.issue9
dc.source.beginpage1
dc.source.endpage15


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