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    Expression of AR-V7 (Androgen receptor variant 7) protein in granular cytoplasmic structures is an independent prognostic factor in prostate cancer patients

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    Author
    König, Paul
    Eckstein, Markus
    Jung, Rudolf
    Abdulrahman, Amer
    Guzman, Juan
    Weigelt, Katrin
    Serrero, Ginette
    Hayashi, Jun
    Geppert, Carol
    Stöhr, Robert
    Hartmann, Arndt
    Wullich, Bernd
    Wach, Sven
    Taubert, Helge
    Lieb, Verena
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    Date
    2020-09-01
    Journal
    Cancers
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cancers12092639
    Abstract
    Prostate cancer (PCa) is the second most common cancer, causing morbidity and mortality among men world-wide. The expression of the androgen receptor (AR) and its splice variants is a crucial factor of prostate cancer biology that has not been comprehensively studied in PCa tumors. The aim of this study was to characterize the protein expression of the AR and its splice variant, AR-V7, and their subcellular distributions in PCa by immunohistochemistry and to correlate the results to the clinicopathological data and prognosis. Immunohistochemical staining for AR and AR-V7 was performed on a tissue microarray (TMA) with specimens from 410 PCa patients using an immunoreactive score (IRS) or only the percentage of AR-V7 staining in cytoplasmic granules. Nuclear or cytoplasmic AR staining was not associated with prognosis. AR-V7 staining was only occasionally observed in the nucleus. However, AR-V7 staining in the cytoplasm or in cytoplasmic granules was associated with relapse-free survival (RFS). AR-V7 staining of the cytoplasm was associated with a shorter RFS, whereas AR-V7 staining of cytoplasmic granules was associated with a longer RFS. In a multivariate Cox’s regression analysis, only negative (<5%) AR-V7 staining of cytoplasmic granules remained an independent prognostic factor for RFS (HR = 5.3; p = 0.006). In a further subgroup analysis by multivariate Cox’s regression analysis, AR-V7 was an independent prognostic factor in the following groups: age ≤ 65 (HR = 9.7; p = 0.029), negative CK20 staining (HR = 7.0; p = 0.008), and positive perineural invasion (HR = 3.7; p = 0.034). Altogether, AR-V7 protein in granular cytoplasmic structures is an independent prognostic factor for RFS in PCa patients.
    Sponsors
    Friedrich-Alexander-Universität Erlangen-Nürnberg
    Keyword
    AR
    AR-V7
    Gleason score
    Perineural invasion
    Prognosis
    Prostate cancer
    Relapse-free survival
    RFS
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13749
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers12092639
    Scopus Count
    Collections
    UMB Open Access Articles 2020

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