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    Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

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    Author
    Schwartz-Duval, Aaron S
    Konopka, Christian J
    Moitra, Parikshit
    Daza, Enrique A
    Srivastava, Indrajit
    Johnson, Elyse V
    Kampert, Taylor L
    Fayn, Stanley
    Haran, Anand
    Dobrucki, Lawrence W
    Pan, Dipanjan
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    Date
    2020-09-10
    Journal
    Nature Communications
    Publisher
    Springer Nature
    Type
    Article
    Other
    
    Metadata
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    See at
    https://doi.org/10.1038/s41467-020-17595-6
    Abstract
    Various cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, particularly considering the millimolar concentrations and longer incubation period of ionic gold. Here, we describe a simplistic method of intracellular biomineralization to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application utilizing polyethylene glycol as delivery vector for ionic gold. We have characterized this process for intracellular gold nanoparticle formation, which progressively accumulates proteins as the ionic gold clusters migrate to the nucleus. This nano-vectorized application of ionic gold emphasizes its potential biomedical opportunities while reducing the quantity of ionic gold and required incubation time. To demonstrate its biomedical potential, we further induce in-situ biosynthesis of gold nanoparticles within MCF7 tumor mouse xenografts which is followed by its photothermal remediation. © 2020, The Author(s).
    Keyword
    biomedical application
    intracellular gold nanoparticle formation
    plasmonic gold nanoparticles
    Cancer
    Biomineralization
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13716
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-020-17595-6
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