Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
Author
Schwartz-Duval, Aaron SKonopka, Christian J
Moitra, Parikshit
Daza, Enrique A
Srivastava, Indrajit
Johnson, Elyse V
Kampert, Taylor L
Fayn, Stanley
Haran, Anand
Dobrucki, Lawrence W
Pan, Dipanjan
Date
2020-09-10Journal
Nature CommunicationsPublisher
Springer NatureType
ArticleOther
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Various cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, particularly considering the millimolar concentrations and longer incubation period of ionic gold. Here, we describe a simplistic method of intracellular biomineralization to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application utilizing polyethylene glycol as delivery vector for ionic gold. We have characterized this process for intracellular gold nanoparticle formation, which progressively accumulates proteins as the ionic gold clusters migrate to the nucleus. This nano-vectorized application of ionic gold emphasizes its potential biomedical opportunities while reducing the quantity of ionic gold and required incubation time. To demonstrate its biomedical potential, we further induce in-situ biosynthesis of gold nanoparticles within MCF7 tumor mouse xenografts which is followed by its photothermal remediation. © 2020, The Author(s).Keyword
biomedical applicationintracellular gold nanoparticle formation
plasmonic gold nanoparticles
Cancer
Biomineralization
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http://hdl.handle.net/10713/13716ae974a485f413a2113503eed53cd6c53
10.1038/s41467-020-17595-6
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