Author
Palma, GiuseppePasqua, Teresa
Silvestri, Giovannino
Rocca, Carmine
Gualtieri, Paola
Barbieri, Antonio
De Bartolo, Anna
De Lorenzo, Antonino
Angelone, Tommaso
Avolio, Ennio
Botti, Gerardo
Date
2020-08-21Journal
Frontiers in Immunology Open AccessPublisher
Frontiers Media S.A.Type
Article
Metadata
Show full item recordAbstract
The spread of the novel human respiratory coronavirus (SARS-CoV-2) is a global public health emergency. There is no known successful treatment as of this time, and there is a need for medical options to mitigate this current epidemic. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor and is primarily trophic for the lower and upper respiratory tract. A number of current studies on COVID-19 have demonstrated the substantial increase in pro-inflammatory factors in the lungs during infection. The virus is also documented in the central nervous system and, particularly in the brainstem, which plays a key role in respiratory and cardiovascular function. Currently, there are few antiviral approaches, and several alternative drugs are under investigation. Two of these are Idelalisib and Ebastine, already proposed as preventive strategies in airways and allergic diseases. The interesting and evolving potential of phosphoinositide 3-kinase δ (PI3Kδ) inhibitors, together with Ebastine, lies in their ability to suppress the release of pro-inflammatory cytokines, such as IL-1β, IL-8, IL-6, and TNF-α, by T cells. This may represent an optional therapeutic choice for COVID-19 to reduce inflammatory reactions and mortality, enabling patients to recover faster. This concise communication aims to provide new potential therapeutic targets capable of mitigating and alleviating SARS-CoV-2 pandemic infection.Sponsors
Agenzia Italiana del Farmaco, Ministero della SaluteIdentifier to cite or link to this item
http://hdl.handle.net/10713/13706ae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2020.02094