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dc.contributor.authorHe, Jiaxi
dc.contributor.authorXu, Songhui
dc.contributor.authorMixson, A James
dc.date.accessioned2020-09-11T16:34:27Z
dc.date.available2020-09-11T16:34:27Z
dc.date.issued2020-08-14
dc.identifier.urihttp://hdl.handle.net/10713/13685
dc.description.abstractHistidines incorporated into carriers of nucleic acids may enhance the extracellular stability of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the release of the nucleic acid. Moreover, protonation of histidines in the endosomes may result in endosomal swelling with subsequent lysis. These properties of histidine are based on its fivemember imidazole ring in which the two nitrogen atoms may form hydrogen bonds or act as a base in acidic environments. A wide variety of carriers have integrated histidines or histidine-rich domains, which include peptides, polyethylenimine, polysaccharides, platform delivery systems, viral phages, mesoporous silica particles, and liposomes. Histidine-rich carriers have played key roles in our understanding of the stability of nanocarriers and the escape of the nucleic acids from endosomes. These carriers show great promise and offer marked potential in delivering plasmids, siRNA, and mRNA to their intracellular targets. © 2020 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/pharmaceutics12080774en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofPharmaceuticsen_US
dc.subjectgene therapyen_US
dc.subjecthistidineen_US
dc.subjectimidazoleen_US
dc.subjectnanoparticlesen_US
dc.subjectnucleic acidsen_US
dc.subjectpeptidesen_US
dc.subjectpolymersen_US
dc.subjectpolyplexesen_US
dc.titleThe Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challengesen_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.doi10.3390/pharmaceutics12080774
dc.identifier.pmid32823960
dc.source.volume12
dc.source.issue8
dc.source.countryUnited States
dc.source.countrySwitzerland


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