• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Research in a time of enteroids and organoids: how the human gut model has transformed the study of enteric bacterial pathogens

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Ranganathan, Sridevi
    Smith, Emily M
    Foulke-Abel, Jennifer D
    Barry, Eileen M
    Date
    2020-11-01
    Journal
    Gut Microbes
    Publisher
    Taylor and Francis Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1080/19490976.2020.1795389
    Abstract
    Enteric bacterial pathogens cause significant morbidity and mortality globally. Studies in tissue culture and animal models shaped our initial understanding of these host-pathogen interactions. However, intrinsic shortcomings in these models limit their application, especially in translational applications like drug screening and vaccine development. Human intestinal enteroid and organoid models overcome some limitations of existing models and advance the study of enteric pathogens. In this review, we detail the use of human enteroids and organoids to investigate the pathogenesis of invasive bacteria Shigella, Listeria, and Salmonella, and noninvasive bacteria pathogenic Escherichia coli, Clostridium difficile, and Vibrio cholerae. We highlight how these studies confirm previously identified mechanisms and, importantly, reveal novel ones. We also discuss the challenges for model advancement, including platform engineering to integrate environmental conditions, innate immune cells and the resident microbiome, and the potential for pre-clinical testing of recently developed antimicrobial drugs and vaccines.
    Keyword
    Human intestinal enteroids
    bacterial pathogens
    enteric bacteria
    organoids
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13649
    ae974a485f413a2113503eed53cd6c53
    10.1080/19490976.2020.1795389
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • A Versatile Human Intestinal Organoid-Derived Epithelial Monolayer Model for the Study of Enteric Pathogens.
    • Authors: Nickerson KP, Llanos-Chea A, Ingano L, Serena G, Miranda-Ribera A, Perlman M, Lima R, Sztein MB, Fasano A, Senger S, Faherty CS
    • Issue date: 2021 Sep 3
    • Intestinal Organoids as a Novel Tool to Study Microbes-Epithelium Interactions.
    • Authors: Nigro G, Hanson M, Fevre C, Lecuit M, Sansonetti PJ
    • Issue date: 2019
    • Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids.
    • Authors: Bartfeld S
    • Issue date: 2016 Dec 15
    • Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut.
    • Authors: Vermeire B, Gonzalez LM, Jansens RJJ, Cox E, Devriendt B
    • Issue date: 2021 Jun 26
    • Organoid and Enteroid Modeling of Salmonella Infection.
    • Authors: Yin Y, Zhou D
    • Issue date: 2018
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.