Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging
Author
Correa-de-Araujo, RosalyAddison, Odessa
Miljkovic, Iva
Goodpaster, Bret H.
Bergman, Bryan C.
Clark, Richard V.
Elena, Joanne W.
Esser, Karyn A.
Ferrucci, Luigi
Harris-Love, Michael O.
Kritchevsky, Steve B.
Lorbergs, Amanda
Shepherd, John A.
Shulman, Gerald I.
Rosen, Clifford J.
Date
2020-08-07Journal
Frontiers in PhysiologyPublisher
Frontiers Media SAType
Article
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Show full item recordAbstract
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An interdisciplinary workshop convened by the National Institute on Aging Division of Geriatrics and Clinical Gerontology on September 2018, discussed myosteatosis in the context of skeletal muscle function deficit (SMFD). Its purpose was to gain a better understanding of the roles of myosteatosis in aging muscles and metabolic disease, particularly its potential determinants and clinical consequences, and ways of properly assessing it. Special attention was given to functional status and standardization of measures of body composition (including the value of D3-creatine dilution method) and imaging approaches [including ways to better use dual-energy X-ray absorptiometry (DXA) through the shape and appearance modeling] to assess lean mass, sarcopenia, and myosteatosis. The workshop convened innovative new areas of scientific relevance to light such as the effect of circadian rhythms and clock disruption in skeletal muscle structure, function, metabolism, and potential contribution to increased myosteatosis. A muscle-bone interaction perspective compared mechanisms associated with myosteatosis and bone marrow adiposity. Potential preventive and therapeutic approaches highlighted ongoing work on physical activity, myostatin treatment, and calorie restriction. Myosteatosis’ impact on cancer survivors raised new possibilities to identify its role and to engage in cross-disciplinary collaboration. A wide range of research opportunities and challenges in planning for the most appropriate study design, interpretation, and translation of findings into clinical practice were discussed and are presented here. © The AuthorsKeyword
agingintermuscular adipose tissue
intramyocellular lipids
mobility-disability
muscle quality
myosteatosis
skeletal muscle function deficit
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http://hdl.handle.net/10713/13643ae974a485f413a2113503eed53cd6c53
10.3389/fphys.2020.00963
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/