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    Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

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    Author
    D’Anneo, Antonella
    Bavisotto, Celeste Caruso
    Gammazza, Antonella Marino
    Paladino, Letizia
    Carlisi, Daniela
    Cappello, Francesco
    de Macario, Everly Conway
    Macario, Alberto J.L.
    Lauricella, Marianna
    Date
    2020-01-01
    Journal
    Cell Stress and Chaperones
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s12192-020-01153-6
    Abstract
    Fatty acid–binding proteins (FABPs) are lipid chaperones assisting in the trafficking of long-chain fatty acids with functions in various cell compartments, including oxidation, signaling, gene-transcription regulation, and storage. The various known FABP isoforms display distinctive tissue distribution, but some are active in more than one tissue. Quantitative and/or qualitative changes of FABPs are associated with pathological conditions. Increased circulating levels of FABPs are biomarkers of disorders such as obesity, insulin resistance, cardiovascular disease, and cancer. Deregulated expression and malfunction of FABPs can result from genetic alterations or posttranslational modifications and can be pathogenic. We have assembled the disorders with abnormal FABPs as chaperonopathies in a distinct nosological entity. This entity is similar but separate from that encompassing the chaperonopathies pertaining to protein chaperones. In this review, we discuss the role of FABPs in the pathogenesis of metabolic syndrome, cancer, and neurological diseases. We highlight the opportunities for improving diagnosis and treatment that open by encompassing all these pathological conditions within of a coherent nosological group, focusing on abnormal lipid chaperones as biomarkers of disease and etiological-pathogenic factors. © 2020, The Author(s).
    Keyword
    Chaperonopathies
    Chaperonotherapy
    Fatty acid–binding proteins
    Lipid chaperone-associate pathologies
    Lipid chaperones
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13632
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12192-020-01153-6
    Scopus Count
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    UMB Open Access Articles 2020

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