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    Rifabutin use in staphylococcus biofilm infections: A case series

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    Author
    Doub, James B.
    Heil, Emily L.
    Ntem-Mensah, Afua
    Neeley, Renaldo
    Ching, Patrick R.
    Date
    2020-06-01
    Journal
    Antibiotics
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/antibiotics9060326
    Abstract
    This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was well tolerated with no side effects. As well, no patients had recurrence of their staphylococcal infections. This case series shows that rifabutin can be a beneficial adjuvant therapy in Staphylococcus biofilm infections when drug–drug interactions limit the use of rifampin. © 2020 by the authors.
    Keyword
    Biofilms
    Drug interactions
    Periprosthetic joint infection
    Rifabutin
    Staphylococcus
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13606
    ae974a485f413a2113503eed53cd6c53
    10.3390/antibiotics9060326
    Scopus Count
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