Aberrant Correlation Between the Default Mode and Salience Networks in Mild Traumatic Brain Injury
JournalFrontiers in Computational Neuroscience
PublisherFrontiers Media S.A.
MetadataShow full item record
AbstractObjectives: The specific intrinsic network coupling abnormalities in mild traumatic brain injury (mTBI) patients are poorly understood. Our objective is to compare the correlations among the default mode, salience, and central executive networks in patients with mTBI and healthy controls. Methods: This 2-year prospective study included 32 acute mTBI patients and 37 healthy comparisons. We calculated the functional connectivity scores among the default mode, salience, and central executive networks. Then we conducted multilevel correlation analysis to investigate component correlations, global graph, and local functional connectivity changes. Results: Patients with mTBI showed significant increased functional connectivity between the anterior part of the default mode network and the salience network compared with controls (p = 0.013, false discovery rate correction). Hyper-connectivity between the default mode and salience network was significantly positively correlated with the dimensional change card sort score in patients with mTBI (r = 0.40, p = 0.037). The average path length of mTBI patients was significantly higher than that of controls (p = 0.028). Conclusions: Aberrant functional coupling between the default mode and salience networks were identified in acute mTBI patients. Our finding has great potential to improve our understanding of the network architecture of mTBI. Copyright The Authors.
SponsorsFunding. This work was supported by the National Natural Science Foundation of China (No. 81771899), Peak Academic Talent Program of Jiangsu Province Hospital of Chinese Medicine (y2018rc04), and Jiangsu Provincial Key Research and Development Program (No. BE2017772).
Keyworddefault mode network
mild traumatic brain injury
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85089315794&doi=10.3389%2ffncom.2020.00068&partnerID=40&md5=26cfbef46d28d96f6b1bbfb53d08c7cd; http://hdl.handle.net/10713/13579
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