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    Human molecular chaperones share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19

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    Author
    Marino Gammazza, Antonella
    Légaré, Sébastien
    Lo Bosco, Giosuè
    Fucarino, Alberto
    Angileri, Francesca
    Conway de Macario, Everly cc
    Macario, Alberto Jl
    Cappello, Francesco
    Date
    2020-08-04
    Journal
    Cell Stress and Chaperones
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s12192-020-01148-3
    Abstract
    Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the cause of COVID-19 disease, has the potential to elicit autoimmunity because mimicry of human molecular chaperones by viral proteins. We compared viral proteins with human molecular chaperones, many of which are heat shock proteins, to determine if they share amino acid-sequence segments with immunogenic-antigenic potential, which can elicit cross-reactive antibodies and effector immune cells with the capacity to damage-destroy human cells by a mechanism of autoimmunity. We identified the chaperones that can putatively participate in molecular mimicry phenomena after SARS-CoV-2 infection, focusing on those for which endothelial cell plasma-cell membrane localization has already been demonstrated. We also postulate that post-translational modifications, induced by physical (shear) and chemical (metabolic) stress caused respectively by the risk factors hypertension and diabetes, might have a role in determining plasma-cell membrane localization and, in turn, autoimmune-induced endothelial damage.
    Keyword
    Autoimmunity
    COVID-19
    Endothelialitis
    Molecular chaperones
    Molecular mimicry
    Severe acute respiratory syndrome coronavirus 2
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13563
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12192-020-01148-3
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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