• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2020
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2020
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Wang, Hannah A
    Liang, Hua-Jun
    Ernst, Thomas M
    Oishi, Kenichi
    Chang, Linda
    Date
    2020-08-06
    Journal
    Journal of Neuroinflammation
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12974-020-01910-5
    Abstract
    OBJECTIVE: Cognitive deficits and microstructural brain abnormalities are well documented in HIV-positive individuals (HIV+). This study evaluated whether chronic marijuana (MJ) use contributes to additional cognitive deficits or brain microstructural abnormalities that may reflect neuroinflammation or neuronal injury in HIV+. METHOD: Using a 2 × 2 design, 44 HIV+ participants [23 minimal/no MJ users (HIV+), 21 chronic active MJ users (HIV + MJ)] were compared to 46 seronegative participants [24 minimal/no MJ users (SN) and 22 chronic MJ users (SN + MJ)] on neuropsychological performance (7 cognitive domains) and diffusion tensor imaging metrics, using an automated atlas to assess fractional anisotropy (FA), axial (AD), radial (RD), and mean (MD) diffusivities, in 18 cortical and 4 subcortical brain regions. RESULTS: Compared to SN and regardless of MJ use, the HIV+ group had lower FA and higher diffusivities in multiple white matter and subcortical structures (p < 0.001-0.050), as well as poorer cognition in Fluency (p = 0.039), Attention/Working Memory (p = 0.009), Learning (p = 0.014), and Memory (p = 0.028). Regardless of HIV serostatus, MJ users had lower AD in uncinate fasciculus (p = 0.024) but similar cognition as nonusers. HIV serostatus and MJ use showed an interactive effect on mean diffusivity in the right globus pallidus but not on cognitive function. Furthermore, lower FA in left anterior internal capsule predicted poorer Fluency across all participants and worse Attention/Working Memory in all except SN subjects, while higher diffusivities in several white matter tracts also predicted lower cognitive domain Z-scores. Lastly, MJ users with or without HIV infection showed greater than normal age-dependent FA declines in superior longitudinal fasciculus, external capsule, and globus pallidus. CONCLUSIONS: Our findings suggest that, except in the globus pallidus, chronic MJ use had no additional negative influence on brain microstructure or neurocognitive deficits in HIV+ individuals. However, lower AD in the uncinate fasciculus of MJ users suggests axonal loss in this white matter tract that connects to cannabinoid receptor rich brain regions that are involved in verbal memory and emotion. Furthermore, the greater than normal age-dependent FA declines in the white matter tracts and globus pallidus in MJ users suggest that older chronic MJ users may eventually have lesser neuronal integrity in these brain regions.
    Keyword
    Cognition
    DTI
    Diffusivity
    Fractional anisotropy
    HIV
    Marijuana
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13561
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12974-020-01910-5
    Scopus Count
    Collections
    UMB Open Access Articles 2020

    entitlement

    Related articles

    • Greater Sensorimotor Deficits and Abnormally Lower Globus Pallidus Fractional Anisotropy in HIV+ Women than in HIV+ Men.
    • Authors: Liang HJ, O'Connor EE, Ernst T, Oishi K, Cunningham E, Chang L
    • Issue date: 2020 Apr 22
    • Independent and Combined Effects of Chronic HIV-Infection and Tobacco Smoking on Brain Microstructure.
    • Authors: Liang H, Chang L, Chen R, Oishi K, Ernst T
    • Issue date: 2018 Dec
    • Brain microstructural development at near-term age in very-low-birth-weight preterm infants: an atlas-based diffusion imaging study.
    • Authors: Rose J, Vassar R, Cahill-Rowley K, Guzman XS, Stevenson DK, Barnea-Goraly N
    • Issue date: 2014 Feb 1
    • Altered white matter microstructure in adolescent substance users.
    • Authors: Bava S, Frank LR, McQueeny T, Schweinsburg BC, Schweinsburg AD, Tapert SF
    • Issue date: 2009 Sep 30
    • Nicotine Effects on White Matter Microstructure in Young Adults.
    • Authors: Kangiser MM, Thomas AM, Kaiver CM, Lisdahl KM
    • Issue date: 2019 Jan 24
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.