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dc.contributor.authorBleiziffer, Sabine
dc.contributor.authorSimonato, Matheus
dc.contributor.authorWebb, John G
dc.contributor.authorRodés-Cabau, Josep
dc.contributor.authorPibarot, Philippe
dc.contributor.authorKornowski, Ran
dc.contributor.authorWindecker, Stephan
dc.contributor.authorErlebach, Magdalena
dc.contributor.authorDuncan, Alison
dc.contributor.authorSeiffert, Moritz
dc.contributor.authorUnbehaun, Axel
dc.contributor.authorFrerker, Christian
dc.contributor.authorConzelmann, Lars
dc.contributor.authorWijeysundera, Harindra
dc.contributor.authorKim, Won-Keun
dc.contributor.authorMontorfano, Matteo
dc.contributor.authorLatib, Azeem
dc.contributor.authorTchetche, Didier
dc.contributor.authorAllali, Abdelhakim
dc.contributor.authorAbdel-Wahab, Mohamed
dc.contributor.authorOrvin, Katia
dc.contributor.authorStortecky, Stefan
dc.contributor.authorNissen, Henrik
dc.contributor.authorHolzamer, Andreas
dc.contributor.authorUrena, Marina
dc.contributor.authorTesta, Luca
dc.contributor.authorAgrifoglio, Marco
dc.contributor.authorWhisenant, Brian
dc.contributor.authorSathananthan, Janarthanan
dc.contributor.authorNapodano, Massimo
dc.contributor.authorLandi, Antonio
dc.contributor.authorFiorina, Claudia
dc.contributor.authorZittermann, Armin
dc.contributor.authorVeulemans, Verena
dc.contributor.authorSinning, Jan-Malte
dc.contributor.authorSaia, Francesco
dc.contributor.authorBrecker, Stephen
dc.contributor.authorPresbitero, Patrizia
dc.contributor.authorDe Backer, Ole
dc.contributor.authorSøndergaard, Lars
dc.contributor.authorBruschi, Giuseppe
dc.contributor.authorFranco, Luis Nombela
dc.contributor.authorPetronio, Anna Sonia
dc.contributor.authorBarbanti, Marco
dc.contributor.authorCerillo, Alfredo
dc.contributor.authorSpargias, Konstantinos
dc.contributor.authorSchofer, Joachim
dc.contributor.authorCohen, Mauricio
dc.contributor.authorMuñoz-Garcia, Antonio
dc.contributor.authorFinkelstein, Ariel
dc.contributor.authorAdam, Matti
dc.contributor.authorSerra, Vicenç
dc.contributor.authorTeles, Rui Campante
dc.contributor.authorChampagnac, Didier
dc.contributor.authorIadanza, Alessandro
dc.contributor.authorChodor, Piotr
dc.contributor.authorEggebrecht, Holger
dc.contributor.authorWelsh, Robert
dc.contributor.authorCaixeta, Adriano
dc.contributor.authorSalizzoni, Stefano
dc.contributor.authorDager, Antonio
dc.contributor.authorAuffret, Vincent
dc.contributor.authorCheema, Asim
dc.contributor.authorUbben, Timm
dc.contributor.authorAncona, Marco
dc.contributor.authorRudolph, Tanja
dc.contributor.authorGummert, Jan
dc.contributor.authorTseng, Elaine
dc.contributor.authorNoble, Stephane
dc.contributor.authorBunc, Matjaz
dc.contributor.authorRoberts, David
dc.contributor.authorKass, Malek
dc.contributor.authorGupta, Anuj
dc.contributor.authorLeon, Martin B
dc.contributor.authorDvir, Danny
dc.date.accessioned2020-08-17T16:57:42Z
dc.date.available2020-08-17T16:57:42Z
dc.date.issued2020-08-01
dc.identifier.urihttp://hdl.handle.net/10713/13558
dc.description.abstractAIMS: Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There are no data on long-term outcomes after aortic ViV. Our aim was to perform a large-scale assessment of long-term survival and reintervention after aortic ViV. METHODS AND RESULTS: A total of 1006 aortic ViV procedures performed more than 5 years ago [mean age 77.7 ± 9.7 years; 58.8% male; median STS-PROM score 7.3% (4.2-12.0)] were included in the analysis. Patients were treated with Medtronic self-expandable valves (CoreValve/Evolut, Medtronic Inc., Minneapolis, MN, USA) (n = 523, 52.0%), Edwards balloon-expandable valves (EBEV, SAPIEN/SAPIEN XT/SAPIEN 3, Edwards Lifesciences, Irvine, CA, USA) (n = 435, 43.2%), and other devices (n = 48, 4.8%). Survival was lower at 8 years in patients with small-failed bioprostheses [internal diameter (ID) ≤ 20 mm] compared with those with large-failed bioprostheses (ID > 20 mm) (33.2% vs. 40.5%, P = 0.01). Independent correlates for mortality included smaller-failed bioprosthetic valves [hazard ratio (HR) 1.07 (95% confidence interval (CI) 1.02-1.13)], age [HR 1.21 (95% CI 1.01-1.45)], and non-transfemoral access [HR 1.43 (95% CI 1.11-1.84)]. There were 40 reinterventions after ViV. Independent correlates for all-cause reintervention included pre-existing severe prosthesis-patient mismatch [subhazard ratio (SHR) 4.34 (95% CI 1.31-14.39)], device malposition [SHR 3.75 (95% CI 1.36-10.35)], EBEV [SHR 3.34 (95% CI 1.26-8.85)], and age [SHR 0.59 (95% CI 0.44-0.78)]. CONCLUSIONS: The size of the original failed valve may influence long-term mortality, and the type of the transcatheter valve may influence the need for reintervention after aortic ViV. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020.en_US
dc.description.urihttps://doi.org/10.1093/eurheartj/ehaa544en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofEuropean Heart Journalen_US
dc.rightsPublished on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.en_US
dc.subjectAortic valve-in-valveen_US
dc.subjectReinterventionen_US
dc.subjectSAPIEN valveen_US
dc.subjectSevere prosthesis–patient mismatchen_US
dc.subjectTAVRen_US
dc.titleLong-term outcomes after transcatheter aortic valve implantation in failed bioprosthetic valvesen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/eurheartj/ehaa544
dc.identifier.pmid32592401
dc.source.volume41
dc.source.issue29
dc.source.beginpage2731
dc.source.endpage2742
dc.source.countryEngland


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