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dc.contributor.authorGore, Maria Odette
dc.contributor.authorAyers, Colby R
dc.contributor.authorKhera, Amit
dc.contributor.authordeFilippi, Christopher R
dc.contributor.authorWang, Thomas J
dc.contributor.authorSeliger, Stephen L
dc.contributor.authorNambi, Vijay
dc.contributor.authorSelvin, Elizabeth
dc.contributor.authorBerry, Jarett D
dc.contributor.authorHundley, W Gregory
dc.contributor.authorBudoff, Matthew
dc.contributor.authorGreenland, Philip
dc.contributor.authorDrazner, Mark H
dc.contributor.authorBallantyne, Christie M
dc.contributor.authorLevine, Benjamin D
dc.contributor.authorde Lemos, James A
dc.date.accessioned2020-08-14T17:56:07Z
dc.date.available2020-08-14T17:56:07Z
dc.date.issued2020-07-23
dc.identifier.urihttp://hdl.handle.net/10713/13556
dc.description.abstractBackground Current strategies for cardiovascular disease (CVD) risk assessment focus on 10-year or longer timeframes. Shorter-term CVD risk is also clinically relevant, particularly for high-risk occupations, but is under-investigated. Methods and Results We pooled data from participants in the ARIC (Atherosclerosis Risk in Communities study), MESA (Multi-Ethnic Study of Atherosclerosis), and DHS (Dallas Heart Study), free from CVD at baseline (N=16 581). Measurements included N-terminal pro-B-type natriuretic peptide (>100 pg/mL prospectively defined as abnormal); high-sensitivity cardiac troponin T (abnormal >5 ng/L); high-sensitivity C-reactive protein (abnormal >3 mg/L); left ventricular hypertrophy by ECG (abnormal if present); carotid intima-media thickness, and plaque (abnormal >75th percentile for age and sex or presence of plaque); and coronary artery calcium (abnormal >10 Agatston U). Each abnormal test result except left ventricular hypertrophy by ECG was independently associated with increased 3-year risk of global CVD (myocardial infarction, stroke, coronary revascularization, incident heart failure, or atrial fibrillation), even after adjustment for traditional CVD risk factors and the other test results. When a simple integer score counting the number of abnormal tests was used, 3-year multivariable-adjusted global CVD risk was increased among participants with integer scores of 1, 2, 3, and 4, by ≈2-, 3-, 4.5- and 8-fold, respectively, when compared with those with a score of 0. Qualitatively similar results were obtained for atherosclerotic CVD (fatal or non-fatal myocardial infarction or stroke). Conclusions A strategy incorporating multiple biomarkers and atherosclerosis imaging improved assessment of 3-year global and atherosclerotic CVD risk compared with a standard approach using traditional risk factors.en_US
dc.description.urihttps://doi.org/10.1161/JAHA.119.015410en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of the American Heart Associationen_US
dc.subjectN‐terminal pro B‐type natriuretic peptideen_US
dc.subjectcarotid intima‐media thicknessen_US
dc.subjectcoronary artery calciumen_US
dc.subjecthigh‐sensitivity C‐reactive proteinen_US
dc.subjecthigh‐sensitivity cardiac troponin Ten_US
dc.subjectplaqueen_US
dc.titleCombining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adultsen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.119.015410
dc.identifier.pmid32698652
dc.source.volume9
dc.source.issue15
dc.source.beginpagee015410
dc.source.endpage
dc.source.countryEngland


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