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dc.contributor.authorBhadila, Ghalia
dc.contributor.authorBaras, Bashayer H.
dc.contributor.authorWeir, Michael D.
dc.contributor.authorWang, Haohao
dc.contributor.authorMelo, Mary Ann S.
dc.contributor.authorHack, Gary D.
dc.contributor.authorBai, Yuxing
dc.contributor.authorXu, Hockin H.K.
dc.date.accessioned2020-08-13T18:44:25Z
dc.date.available2020-08-13T18:44:25Z
dc.date.issued2020-07-30
dc.identifier.urihttp://hdl.handle.net/10713/13549
dc.description.abstractShort-term studies on calcium-phosphate (CaP) ion-rechargeable composites were reported. The long-term rechargeability is important but unknown. The objectives of this study were to investigate nanocomposite with strong antibacterial and ion-recharge capabilities containing dimethylaminododecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and evaluate long-term ion-recharge by testing for 12 cycles (taking 6 months to complete) for the first time. Three groups were tested: (1) Heliomolar control; (2) Resin+20%NACP+50%glass; (3) Resin+3%DMAHDM+20%NACP+50%glass. Biofilm acid and colony-forming units (CFU) were measured. Ion-recharge was tested for 12 cycles. NACP-DMAHDM composite reduced biofilm acid, and reduced CFU by 4 logs. High levels of ion releases were maintained throughout 12 cycles of recharge, maintaining steady-state releases without reduction in 6 months (p>0.1), representing long-term remineralization potential. Bioactive nanocomposite demonstrated long-term ion-rechargeability for the first time, showed remineralization and potent anti-biofilm functions, with promise for tooth restorations to combat caries.en_US
dc.description.sponsorshipThis work was supported by University of Maryland Baltimore PhD graduate program, Beijing Hospitals’ Program ZYLX201703 (YB), University of Maryland School of Dentistry bridging fund (HX), and University of Maryland Baltimore seed grant (HX).en_US
dc.description.urihttps://doi.org/10.4012/dmj.2019-203en_US
dc.language.isoen_USen_US
dc.publisherNihon Shika Riko Gakkai/Japanese Society for Dental Materials and Devicesen_US
dc.relation.ispartofDental Materials Journalen_US
dc.subjectCalcium phosphate nanoparticlesen_US
dc.subjectDental cariesen_US
dc.subjectDental compositeen_US
dc.subjectDimethylaminododecyl methacrylateen_US
dc.subjectIon recharge and re-releaseen_US
dc.titleNovel antibacterial calcium phosphate nanocomposite with long-term ion recharge and re-release to inhibit cariesen_US
dc.typeArticleen_US
dc.identifier.doi10.4012/dmj.2019-203
dc.identifier.pmid32295987
dc.identifier.scopusidSCOPUS_ID:85089117653
dc.source.volume39
dc.source.issue4
dc.source.beginpage678
dc.source.endpage689


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