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    Novel antibacterial calcium phosphate nanocomposite with long-term ion recharge and re-release to inhibit caries

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    Author
    Bhadila, Ghalia
    Baras, Bashayer H.
    Weir, Michael D.
    Wang, Haohao
    Melo, Mary Ann S.
    Hack, Gary D.
    Bai, Yuxing
    Xu, Hockin H.K.
    Date
    2020-07-30
    Journal
    Dental Materials Journal
    Publisher
    Nihon Shika Riko Gakkai/Japanese Society for Dental Materials and Devices
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.4012/dmj.2019-203
    Abstract
    Short-term studies on calcium-phosphate (CaP) ion-rechargeable composites were reported. The long-term rechargeability is important but unknown. The objectives of this study were to investigate nanocomposite with strong antibacterial and ion-recharge capabilities containing dimethylaminododecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and evaluate long-term ion-recharge by testing for 12 cycles (taking 6 months to complete) for the first time. Three groups were tested: (1) Heliomolar control; (2) Resin+20%NACP+50%glass; (3) Resin+3%DMAHDM+20%NACP+50%glass. Biofilm acid and colony-forming units (CFU) were measured. Ion-recharge was tested for 12 cycles. NACP-DMAHDM composite reduced biofilm acid, and reduced CFU by 4 logs. High levels of ion releases were maintained throughout 12 cycles of recharge, maintaining steady-state releases without reduction in 6 months (p>0.1), representing long-term remineralization potential. Bioactive nanocomposite demonstrated long-term ion-rechargeability for the first time, showed remineralization and potent anti-biofilm functions, with promise for tooth restorations to combat caries.
    Sponsors
    This work was supported by University of Maryland Baltimore PhD graduate program, Beijing Hospitals’ Program ZYLX201703 (YB), University of Maryland School of Dentistry bridging fund (HX), and University of Maryland Baltimore seed grant (HX).
    Keyword
    Calcium phosphate nanoparticles
    Dental caries
    Dental composite
    Dimethylaminododecyl methacrylate
    Ion recharge and re-release
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13549
    ae974a485f413a2113503eed53cd6c53
    10.4012/dmj.2019-203
    Scopus Count
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    UMB Open Access Articles 2020

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