Novel antibacterial calcium phosphate nanocomposite with long-term ion recharge and re-release to inhibit caries
Author
Bhadila, GhaliaBaras, Bashayer H.
Weir, Michael D.
Wang, Haohao
Melo, Mary Ann S.
Hack, Gary D.
Bai, Yuxing
Xu, Hockin H.K.
Date
2020-07-30Journal
Dental Materials JournalPublisher
Nihon Shika Riko Gakkai/Japanese Society for Dental Materials and DevicesType
Article
Metadata
Show full item recordAbstract
Short-term studies on calcium-phosphate (CaP) ion-rechargeable composites were reported. The long-term rechargeability is important but unknown. The objectives of this study were to investigate nanocomposite with strong antibacterial and ion-recharge capabilities containing dimethylaminododecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and evaluate long-term ion-recharge by testing for 12 cycles (taking 6 months to complete) for the first time. Three groups were tested: (1) Heliomolar control; (2) Resin+20%NACP+50%glass; (3) Resin+3%DMAHDM+20%NACP+50%glass. Biofilm acid and colony-forming units (CFU) were measured. Ion-recharge was tested for 12 cycles. NACP-DMAHDM composite reduced biofilm acid, and reduced CFU by 4 logs. High levels of ion releases were maintained throughout 12 cycles of recharge, maintaining steady-state releases without reduction in 6 months (p>0.1), representing long-term remineralization potential. Bioactive nanocomposite demonstrated long-term ion-rechargeability for the first time, showed remineralization and potent anti-biofilm functions, with promise for tooth restorations to combat caries.Sponsors
This work was supported by University of Maryland Baltimore PhD graduate program, Beijing Hospitals’ Program ZYLX201703 (YB), University of Maryland School of Dentistry bridging fund (HX), and University of Maryland Baltimore seed grant (HX).Keyword
Calcium phosphate nanoparticlesDental caries
Dental composite
Dimethylaminododecyl methacrylate
Ion recharge and re-release
Identifier to cite or link to this item
http://hdl.handle.net/10713/13549ae974a485f413a2113503eed53cd6c53
10.4012/dmj.2019-203