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    Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions

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    Author
    Landers-Ramos, Rian Q
    Addison, Odessa A
    Beamer, Brock
    Katzel, Leslie I
    Blumenthal, Jacob B
    Robinson, Shawn
    Hagberg, James M
    Prior, Steven J
    Date
    2020-08
    Journal
    Physiological Reports
    Publisher
    Wiley-Blackwell
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.14814/phy2.14534
    Abstract
    Concentrations of different circulating microparticles (MPs) may have clinical and physiological relevance to cardiovascular disease pathologies. PURPOSE: To quantify plasma concentrations of CD31+/CD42b-, CD62E+, and CD34+ MPs across healthy individuals and those with coronary artery disease (CAD) or acute cardiovascular events (non-ST elevation myocardial infarction (NSTEMI)). Fasted blood was obtained from CAD patients (n = 10), NSTEMI patients (n = 13), and healthy older men (n = 15) 60-75 years old. METHODS: CD31+/CD42b-, CD62E+, and CD34+ MPs were isolated from plasma and quantified using flow cytometry. Relationships between MP subtypes, fasting blood lipids, blood glucose, blood pressure, body mass index, and total number of medications were assessed. RESULTS: Concentrations of CD31+/CD42b- MPs were significantly lower in CAD and NSTEMI subjects compared with healthy individuals (p = .02 and .003, respectively). No differences between groups were found for CD62E+ or CD34+ MPs (p > .05 for both). Surprisingly, among all variables assessed, only CD62E+ MP concentrations were positively correlated with triglyceride levels (p = .012) and inversely correlated with SBP (p = .03). CONCLUSIONS: Our findings provide support for the use of different MP subtypes, specifically CD31+/CD42b- MPs, as a potential biomarker of cardiovascular disease. Importantly, results from this study should be looked at in adjunct to previous MP work in CVD conditions as a way of highlighting the complex interactions of variables such as comorbid conditions and medications on MP concentrations. © 2020 The Authors.
    Rights/Terms
    © 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
    Keyword
    NSTEMI
    cardiovascular disease
    coronary artery disease
    endothelial microparticles
    microparticles
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13546
    ae974a485f413a2113503eed53cd6c53
    10.14814/phy2.14534
    Scopus Count
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    UMB Open Access Articles 2020

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