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    Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation

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    Author
    Li, Jia-Heng
    Yang, Jia-Le
    Wei, Si-Qi
    Li, Zhuo-Lin
    Collins, Anna A
    Zou, Min
    Wei, Feng
    Cao, Dong-Yuan
    Date
    2020-07-28
    Journal
    Molecular Brain
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s13041-020-00645-x
    Abstract
    Temporomandibular disorder (TMD) is commonly comorbid with fibromyalgia syndrome (FMS). The incidence of these pain conditions is prevalent in women and prone to mental stress. Chronic pain symptoms in patients with FMS and myofascial TMD (mTMD) are severe and debilitating. In the present study, we developed a new animal model to mimic the comorbidity of TMD and FMS. In ovariectomized female rats, repeated forced swim (FS) stress induced mechanical allodynia and thermal hyperalgesia in the hindpaws of the 17β-estradiol (E2) treated rats with orofacial inflammation. Subcutaneous injection of E2, injection of complete Freund's adjuvant (CFA) into masseter muscles or FS alone did not induce somatic hyperalgesia. We also found that the somatic hyperalgesia was accompanied by upregulation of GluN1 receptor and serotonin (5-hydroxytryptamine, 5-HT)3A receptor expression in the dorsal horn of spinal cord at L4-L5 segments. Intrathecal injection of N-methyl-D-aspartic acid receptor (NMDAR) antagonist 2-amino-5-phosphonovaleric acid (APV) or 5-HT3 receptor antagonist Y-25130 blocked stress-induced wide-spreading hyperalgesia. These results suggest that NMDAR-dependent central sensitization in the spinal dorsal horn and 5-HT-dependent descending facilitation contribute to the development of wide-spreading hyperalgesia in this comorbid pain model.
    Keyword
    Central sensitization
    Comorbidity
    Hyperalgesia
    Orofacial inflammation
    Stress
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13536
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13041-020-00645-x
    Scopus Count
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    UMB Open Access Articles 2020

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