Show simple item record

dc.contributor.authorElnaggar, Manar
dc.date.accessioned2020-08-12T15:38:57Z
dc.date.available2020-08-12T15:38:57Z
dc.date.issued2020en_US
dc.identifier.urihttp://hdl.handle.net/10713/13522
dc.description2020
dc.descriptionOral and Experimental Pathology
dc.descriptionUniversity of Maryland, Baltimore
dc.descriptionM.S.
dc.description.abstractProgrammed death ligand 1 (PD-L1) is an immune-checkpoint regulator. Expression of PD-L1 in a subset of head and neck squamous cell carcinoma (HNSCC) was linked to improved response to immunotherapy. Oral potentially malignant disorders (OPMDs) are characterized by increased risk for malignant transformation. We investigated the expression of PD-L1 in immune cells (ICs) and epithelial cells of OPMD, which is essential to prevent progression to malignancy. Immunohistochemistry analyses in HNSCC whole excision tissue sections (104 patients) indeed demonstrated predominant expression of PD-L1 in the epithelial margins (~86%). This directly correlated with PD-L1 expression in underlying ICs (P=0.0172) with a predominating lichenoid pattern of IC infiltrate. Immunoblotting analyses demonstrated the role of human recombinant IFN-γ in the upregulation of PD-L1 expression in the oral premalignant cell line (DOK) with implications of downstream activation of pS6. Our work suggests a role for IFN-γ/PD-L1 in the immune escape of OPMDs.
dc.subjectIFN-γ
dc.subjectimmune cellen_US
dc.subjectoralen_US
dc.subjectPD-L1en_US
dc.subjectpotentially malignanten_US
dc.subject.meshB7-H1 Antigenen_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshInterferon-gammaen_US
dc.subject.meshSquamous Cell Carcinoma of the Head and Necken_US
dc.titleProgrammed Death Ligand 1 in Oral Potentially Malignant Epithelium and Implications of Regulation by Interferon Gammaen_US
dc.typedissertationen_US
dc.date.updated2020-08-08T13:01:29Z
dc.language.rfc3066en
dc.contributor.advisorYounis, Rania H.
refterms.dateFOA2020-08-12T15:38:58Z


Files in this item

Thumbnail
Name:
Elnaggar_umaryland_0373N_11185.pdf
Size:
1.885Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record