• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Programmed Death Ligand 1 in Oral Potentially Malignant Epithelium and Implications of Regulation by Interferon Gamma

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Elnaggar_umaryland_0373N_11185.pdf
    Size:
    1.885Mb
    Format:
    PDF
    Download
    Author
    Elnaggar, Manar cc
    Advisor
    Younis, Rania H.
    Date
    2020
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Programmed death ligand 1 (PD-L1) is an immune-checkpoint regulator. Expression of PD-L1 in a subset of head and neck squamous cell carcinoma (HNSCC) was linked to improved response to immunotherapy. Oral potentially malignant disorders (OPMDs) are characterized by increased risk for malignant transformation. We investigated the expression of PD-L1 in immune cells (ICs) and epithelial cells of OPMD, which is essential to prevent progression to malignancy. Immunohistochemistry analyses in HNSCC whole excision tissue sections (104 patients) indeed demonstrated predominant expression of PD-L1 in the epithelial margins (~86%). This directly correlated with PD-L1 expression in underlying ICs (P=0.0172) with a predominating lichenoid pattern of IC infiltrate. Immunoblotting analyses demonstrated the role of human recombinant IFN-γ in the upregulation of PD-L1 expression in the oral premalignant cell line (DOK) with implications of downstream activation of pS6. Our work suggests a role for IFN-γ/PD-L1 in the immune escape of OPMDs.
    Description
    2020
    Oral and Experimental Pathology
    University of Maryland, Baltimore
    M.S.
    Keyword
    IFN-γ
    immune cell
    oral
    PD-L1
    potentially malignant
    B7-H1 Antigen
    Cell Transformation, Neoplastic
    Epithelial Cells
    Interferon-gamma
    Squamous Cell Carcinoma of the Head and Neck
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13522
    Collections
    Theses and Dissertations School of Dentistry
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.